Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro.

@article{Gramoun2007EffectsOV,
  title={Effects of Vitaxin, a novel therapeutic in trial for metastatic bone tumors, on osteoclast functions in vitro.},
  author={Azza Gramoun and Seema Shorey and Jill D Bashutski and S. Jeffrey Dixon and Stephen Michael Sims and Johan N. M. Heersche and Morris Frank Manolson},
  journal={Journal of cellular biochemistry},
  year={2007},
  volume={102 2},
  pages={341-52}
}
The integrin alphavbeta3 mediates cell-matrix interactions. Vitaxin(R), a humanized monoclonal antibody that blocks human and rabbit alphavbeta3 integrins, is in clinical trials for metastatic melanoma and prostate cancer. alphavbeta3 is the predominant integrin on osteoclasts, the cells responsible for bone resorption in health and disease. Here, we report the first investigation of Vitaxin's effects on osteoclast activity. Vitaxin (100-300 ng/ml) decreased total resorption by 50%, but did not… CONTINUE READING

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