Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats

  title={Effects of Vitamin E on Bone Biomechanical and Histomorphometric Parameters in Ovariectomized Rats},
  author={Rafaela G Feresin and Sarah A. Johnson and Marcus L. Elam and Jeong-Su Kim and Dania A. Khalil and Edralin A Lucas and Brenda J Smith and Mark Edward Payton and Mohammed P. Akhter and Bahram H Arjmandi},
  booktitle={Journal of osteoporosis},
The present study examined the dose-dependent effect of vitamin E in reversing bone loss in ovariectomized (Ovx) rats. Sprague-Dawley rats were either Sham-operated (Sham) or Ovx and fed control diet for 120 days to lose bone. Subsequently, rats were divided into 5 groups (n = 12/group): Sham, Ovx-control, low dose (Ovx + 300 mg/kg diet; LD), medium dose (Ovx + 525 mg/kg diet; MD), and high dose (Ovx + 750 mg/kg diet; HD) of vitamin E and sacrificed after 100 days. Animals receiving MD and HD… CONTINUE READING
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