Effects of Vitamin D Supplementation on Prevention of Type 2 Diabetes in Patients With Prediabetes: A Systematic Review and Meta-analysis

@article{Zhang2020EffectsOV,
  title={Effects of Vitamin D Supplementation on Prevention of Type 2 Diabetes in Patients With Prediabetes: A Systematic Review and Meta-analysis},
  author={Yu Zhang and Huiwen Tan and Jingjing Tang and Jing Li and Weelic Chong and Yang Hai and Yuning Feng and Lawrence Dade Lunsford and Ping Xu and Desheng Jia and Fang Fang},
  journal={Diabetes Care},
  year={2020},
  volume={43},
  pages={1650 - 1658}
}
BACKGROUND While observational studies have shown an association between vitamin D insufficiency and diabetes, it is unclear whether intervention with vitamin D supplements can lower the risk of type 2 diabetes mellitus (T2DM). PURPOSE To assess whether vitamin D supplementation reduces the risk of T2DM in people with prediabetes. DATA SOURCES We searched MEDLINE, Embase, and Cochrane Central Register of Controlled Trials (CENTRAL) from inception to 5 July 2019. STUDY SELECTION We included… 

Figures and Tables from this paper

Vitamin D Supplementation for Prevention of Type 2 Diabetes Mellitus: To D or Not to D?
TLDR
Results from recent trials are congruent with a large body of evidence from observational studies indicating that vitamin D has a role in modulating diabetes risk and participant-level meta-analysis of the 3 largest trials should provide a more refined estimate of risk reduction.
Effect of Vitamin D Supplementation on Kidney Function in Adults with Prediabetes: A Secondary Analysis of a Randomized Trial.
TLDR
Vitamin D supplementation did not affect progression of KDIGO risk scores and did not have a meaningful effect on change in UACR or eGFR, and among persons with prediabetes, this study found.
Effect of active vitamin D treatment on development of type 2 diabetes: DPVD randomised controlled trial in Japanese population
TLDR
Although treatment with eldecalcitol did not significantly reduce the incidence of diabetes among people with pre-diabetes, the results suggested the potential for a beneficial effect of eldecAlcitol on people with insufficient insulin secretion.
Intratrial Exposure to Vitamin D and New-Onset Diabetes Among Adults With Prediabetes: A Secondary Analysis From the Vitamin D and Type 2 Diabetes (D2d) Study
TLDR
Daily vitamin D supplementation to maintain a serum 25(OH)D level ≥100 nmol/L is a promising approach to reducing the risk of diabetes in adults with prediabetes.
The effect of vitamin D supplementation on glycemic status of elderly people with prediabetes: a 12-month open-label, randomized-controlled study
TLDR
Vitamin D could be complementary to lifestyle change strategy for the management of prediabetes in the elderly as well as improving the glycemic status of elderly people with predi diabetes.
Therapeutic effects of dietary antioxidative supplements on the management of type 2 diabetes and its complications; umbrella review of observational/trials meta-analysis studies
TLDR
It is suggested that dietary vitamins and nutrients can result in protective impacts the complications associated with T2DM, however, due to discrepancies between the results of the trials and observational studies is essential to conduct long-term high-qualified studies to prove the beneficial therapeutic effects of the vitamin and nutrients.
The health effects of vitamin D supplementation: evidence from human studies
TLDR
Results from large randomized clinical trials performed during the period 2017–2020 and Mendelian randomization studies on vitamin D levels indicate that vitamin D supplementation alone in vitamin D-replete adults does not provide health benefits; however, vitamin D deficiency should always be corrected.
Investigation of the clinical outcomes of long-term vitamin D supplementation in Egyptian Type 2 Diabetes Mellitus patients
TLDR
As there was a significant improvement in glycemic, inflammatory, and oxidative stress parameters in type 2 diabetes mellitus patients, vitamin D supplementation has a promising effect on the treatment of type 2 Diabetes Mellitus.
Effects of vitamin D supplementation on insulin sensitivity and secretion in prediabetes.
CONTEXT Vitamin D regulates glucose homeostasis pathways, but effects of vitamin D supplementation on insulin sensitivity and β-cell function remain unclear. OBJECTIVE To investigate the effects of
The Influence of Vitamin D Intake and Status on Mental Health in Children: A Systematic Review
TLDR
The vast majority of assessed studies, including the most prominent ones (based on the NOS score) supported potential positive influence of vitamin D on mental health in children, so it should be recommended to meet the required 25(OH)cholecalciferol blood level in order to prevent or alleviate mental health problems.
...
...

References

SHOWING 1-10 OF 64 REFERENCES
Clinical review: Effect of vitamin D3 supplementation on improving glucose homeostasis and preventing diabetes: a systematic review and meta-analysis.
TLDR
Evidence from available trials shows no effect of vitamin D3 supplementation on glucose homeostasis or diabetes prevention, and definitive conclusions may be limited in the context of the moderate degree of heterogeneity, variable risk of bias, and short-term follow-up duration of the available evidence.
Effects of Vitamin D Supplementation on Glucose and Insulin Homeostasis and Incident Diabetes among Nondiabetic Adults: A Meta-Analysis of Randomized Controlled Trials
TLDR
It is found that vitamin D supplementation might improve glucose and insulin metabolism without affecting the risk of T2D among nondiabetic adults.
Effect of Vitamin D supplementation on glycemic parameters and progression of prediabetes to diabetes: A 1-year, open-label randomized study
TLDR
Vitamin D supplementation in prediabetes subjects significantly lowered FPG, 2-h plasma glucose and A1C levels, and seven out of 64 subjects in the Vitamin D supplemented group developed diabetes.
Effect of vitamin D supplementation on fasting plasma glucose, insulin resistance and prevention of type 2 diabetes mellitus in non-diabetics: A systematic review and meta-analysis.
TLDR
It is suggested that vitamin D supplementation had no significant effect on controlling FPG level, improving insulin resistance or preventing T2DM in non-diabetics in a pooled meta-analysis of 23 articles (containing 28 RCTs), however, stratified analysis indicated that supplementation of vitamin D had differential effects on FPG control, insulin sensitivity improvement and T2 DM prevention in individuals with different baseline states.
The role of vitamin D and calcium in type 2 diabetes. A systematic review and meta-analysis.
TLDR
Evidence from trials with vitamin D and/or calcium supplementation suggests that combined Vitamin D and calcium supplementation may have a role in the prevention of type 2 DM only in populations at high risk (i.e. glucose intolerance).
Vitamin D Supplementation, Glycemic Control, and Insulin Resistance in Prediabetics: A Meta-Analysis
TLDR
A meta-analysis of controlled clinical trials that assessed glycemic outcome measures among adults at risk for type 2 diabetes revealed that vitamin D supplementation and improved vitamin D status improved glycemic measures and insulin sensitivity and may be useful as part of a preventive strategy for type 1 diabetes.
Vitamin D 20,000 IU per Week for Five Years Does Not Prevent Progression From Prediabetes to Diabetes.
TLDR
In subjects without vitamin D deficiency, vitamin D supplementation is unlikely to prevent progression from prediabetes to diabetes, and very large studies with inclusion of vitamin D-deficient subjects will probably be needed to show such a putative effect.
Vitamin D Supplementation and Prevention of Type 2 Diabetes.
TLDR
Among persons at high risk for type 2 diabetes not selected for vitamin D insufficiency, vitamin D3 supplementation at a dose of 4000 IU per day did not result in a significantly lower risk of diabetes than placebo.
EFFECT OF HIGH-DOSE VITAMIN D REPLETION ON GLYCEMIC CONTROL IN AFRICAN-AMERICAN MALES WITH PREDIABETES AND HYPOVITAMINOSIS D.
TLDR
The trial does not provide evidence that 12 months of high-dose D2 repletion improves clinically relevant glycemic outcomes in subjects with prediabetes and hypovitaminosis D.
...
...