Effects of Vitamin D Supplementation on Blood Pressure

@article{Wu2010EffectsOV,
  title={Effects of Vitamin D Supplementation on Blood Pressure},
  author={Sheng Hui Wu and Suzanne C. Ho and Liu Zhong},
  journal={Southern Medical Journal},
  year={2010},
  volume={103},
  pages={729-737}
}
Objective: Inconsistent findings from epidemiological studies have continued the controversy over the role of oral vitamin D supplementation in reducing blood pressure in normotensive or hypertensive populations. Methods: We performed a literature search up to December 2009, with no restrictions. Only double-blind randomized controlled trials (RCTs) of oral vitamin D supplementation in normotensive or hypertensive individuals with blood pressure measurements were included. Results: From 244… 
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116 Citations
Highly Influential Citations
4
Background Citations
32
Methods Citations
3
Results Citations
5

116 Citations

Effect of vitamin D3 supplementation on blood pressure in adults: An updated meta-analysis.

Effect of vitamin D supplementation on blood pressure parameters in patients with vitamin D deficiency: a systematic review and meta-analysis.

The effect of vitamin D supplementation on hypertension in non-CKD populations: A systemic review and meta-analysis.

Effect of Calcitriol Supplementation on Blood Pressure in Older Adults

1,000 IU/day of calcitriol for 6 weeks efficiently reduced systolic and diastolic blood pressure levels in this population of older adults presenting with high blood pressure (Clinical Trial Approbation NCT02047799).

Effect of Vitamin D Supplementation on Blood Pressure: A Systematic Review and Meta-analysis Incorporating Individual Patient Data.

Vitamin D supplementation is ineffective as an agent for lowering BP and thus should not be used as an antihypertensive agent.

Does vitamin D modulate blood pressure?

Large randomized trials focusing on patients with severe vitamin D deficiency and hypertension are needed before vitamin D can be recommended for the prevention or treatment of hypertension.

Effect of vitamin D supplementation on cardiovascular disease risk factors and exercise performance in healthy participants: a randomized placebo-controlled preliminary study

It is suggested that daily vitamin D supplementation may ameliorate CVD risk factors including a decrease in 11β-HSD1 activity, as evidenced by the decrease in the cortisol/cortisone ratio, and improve exercise performance in healthy individuals.

Blood Pressure in Healthy Youngsters is modified by Vitamin-D Supplementation

It was observed that 180 days of vitamin D supplementation in normal youngsters with insufficient vitamin D significantly lowered systolic and diastolic BP during daytime and it is tempting to conclude that vitamin D acts on BP through SNS as no changes were observed in the RAAS.

Vitamin D supplementation effects on the clinical outcomes of patients with coronary artery disease: a systematic review and meta-analysis

The use of vitamin D was associated with improvements in some cardiac outcomes of CAD patients with vitamin D deficiency, and it had no significant effects on hs-CRP mean difference.

Vitamin D and hypertension: an update and review

Further research is needed before clinical practice recommends vitamin D prescription as treatment for hypertension in the general population, as data from cross-sectional studies report that low 25-hydroxy vitamin D is associated with higher systolic blood pressure and higher incidence of hypertension.
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References

SHOWING 1-10 OF 59 REFERENCES

Effect of vitamin D on blood pressure: a systematic review and meta-analysis

Evidence is found to support a small effect of vitamin D on blood pressure in studies of hypertensive patients, and subgroup analysis suggested that unactivated vitamin D produced a greater fall in systolic blood pressure than activated vitamin D.

Effect of Calcium and Vitamin D Supplementation on Blood Pressure: The Women's Health Initiative Randomized Trial

In postmenopausal women, calcium plus vitamin D3 supplementation did not reduce either blood pressure or the risk of developing hypertension over 7 years of follow-up.

Effect of winter oral vitamin D3 supplementation on cardiovascular risk factors in elderly adults.

The failure of vitamin D supplementation to change blood pressure or serum cholesterol suggests that the winter increase in these factors is not caused by decreased vitamin D levels.

No significant effect of calcium and vitamin D supplementation on blood pressure and calcium metabolism in elderly Chinese.

The data suggest that oral supplements of 800 mg calcium or 5 micrograms vitamin D daily produce no significant effect on blood pressure in the elderly in 11 weeks.

Optimal vitamin D status attenuates the age-associated increase in systolic blood pressure in white Americans: results from the third National Health and Nutrition Examination Survey.

SBP is inversely associated with serum vitamin D concentrations in nonhypertensive white persons in the United States, providing a rationale for studies on the potential effects of vitamin D supplementation as a method to reduce SBP in persons at risk of hypertension.

Effects of dietary calcium supplementation on blood pressure. A meta-analysis of randomized controlled trials.

Calcium supplementation may lead to a small reduction in systolic but not diastolic blood pressure, and further studies should address the hypothesis that inadequate calcium intake is associated with increased blood pressure that can be corrected with calcium supplementation.

Reduction of blood pressure by treatment with alphacalcidol. A double-blind, placebo-controlled study in subjects with impaired glucose tolerance.

The findings are compatible with the concept that calcium metabolism influences blood pressure regulation and suggest that supplementation with a physiologic dose of active vitamin D could be beneficial for patients with high blood pressure.

Vitamin D, glucose tolerance and insulinaemia in elderly men

Vitamin D status was assessed in 142 elderly Dutchmen participating in a prospective population-based study of environmental factors in the aetiology of non-insulin-dependent diabetes mellitus andHypovitaminosis D may be a significant risk factor for glucose intolerance.

Supplementation with calcium + vitamin D enhances the beneficial effect of weight loss on plasma lipid and lipoprotein concentrations.

Consumption of calcium+D during a weight-loss intervention enhanced the beneficial effect of body weight loss on the lipid and lipoprotein profile in overweight or obese women with usual low daily calcium intake.

Effects of a short-term vitamin D(3) and calcium supplementation on blood pressure and parathyroid hormone levels in elderly women.

The hypothesis is that short-term therapy with calcium and vitamin D(3) may improve blood pressure as well as secondary hyperparathyroidism more effectively than calcium monotherapy.
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