Effects of Valproic Acid on Longitudinal Bone Growth

  title={Effects of Valproic Acid on Longitudinal Bone Growth},
  author={Shufang Wu and A. Legido and F. De Luca},
  journal={Journal of Child Neurology},
  pages={26 - 30}
  • Shufang Wu, A. Legido, F. De Luca
  • Published 2004
  • Chemistry, Medicine
  • Journal of Child Neurology
  • Valproic acid is widely used in the treatment of children with epilepsy. Evidence indicates that valproic acid has teratogenic effects on the skeletal system. In addition, the use of valproic acid in children has been associated with short stature. Thus, we hypothesized that valproic acid could also affect bone growth after skeletal morphogenesis is completed. To test this hypothesis, we cultured fetal rat metatarsal bones in the presence of valproic acid. Valproic acid markedly suppressed… CONTINUE READING
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