Effects of Valproic Acid on Longitudinal Bone Growth

@article{Wu2004EffectsOV,
  title={Effects of Valproic Acid on Longitudinal Bone Growth},
  author={Shufang Wu and Agust{\'i}n Legido and Francesco De Luca},
  journal={Journal of Child Neurology},
  year={2004},
  volume={19},
  pages={26 - 30}
}
Valproic acid is widely used in the treatment of children with epilepsy. Evidence indicates that valproic acid has teratogenic effects on the skeletal system. In addition, the use of valproic acid in children has been associated with short stature. Thus, we hypothesized that valproic acid could also affect bone growth after skeletal morphogenesis is completed. To test this hypothesis, we cultured fetal rat metatarsal bones in the presence of valproic acid. Valproic acid markedly suppressed… 
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Valproic Acid Impacts the Growth of Growth Plate Chondrocytes
TLDR
The use of VPA in children should be closely monitored or replaced, where appropriate, by AEDs which do not apparently affect the growth plate chondrocytes.
Stanniocalcin 1 Acts as a Paracrine Regulator of Growth Plate Chondrogenesis*
TLDR
The findings indicate that STC1 inhibits longitudinal bone growth directly at the growth plate, which results from suppressed chondrocyte proliferation, hypertrophy/differentiation, and matrix synthesis and by increased apoptosis.
The effect of VPA on bone: From clinical studies to cell cultures—The molecular mechanisms revisited
Bone health in young women with epilepsy after one year of antiepileptic drug monotherapy
TLDR
In women receiving phenytoin, lower serum 25-hydroxyvitamin D concentrations were associated with higher parathyroid hormone, bone alkaline phosphatase, and urine N-telopeptide levels, a biochemical pattern consistent with secondary hyperparathyroidism and increased remodeling.
Inhibition of the proteasomal function in chondrocytes down-regulates growth plate chondrogenesis and longitudinal bone growth.
TLDR
It is suggested that the proteasomal activity facilitates growth plate chondrogenesis and, in turn, longitudinal bone growth.
Valproat und Knochenstoffwechsel
TLDR
Measurement of bone mineral density at regular intervals as well as individual therapy in collaboration with a specialist for bone metabolism is advisable.
Endocrine function and growth in young patients with childhood- or adolescence-onset epilepsy
TLDR
Elevated serum androgen levels, PCOS and overweight are common if epilepsy and AED use, especially VPA, continue into young adulthood, but untoward changes or alterations in serum thyroid hormone or lipid concentrations are not present in young women with medication withdrawn.
Intermittent activation of notch signaling promotes bone formation.
TLDR
It is shown that Notch signaling is activated in osteocytes embedded within the mineralized matrix and in late stages of bone marrow mesenchymal cell osteogenic cultures, and valproic acid, resveratrol and other Notch activators are promising therapeutic molecules for promoting anabolic bone formation when administered intermittently.
Epilepsy treatment by sacrificing vitamin D
TLDR
In this review, vitamin D metabolism and the effect of vitamin D in the brain are described and the literature in terms ofitamin D deficiency and antiepileptic treatment in the pediatric population is discussed.
Evaluation of toxic effects of Trigonella foenum-graecum leaf aqueous extract on development of long bone tissue in rat fetus.
TLDR
It showed that the extract has adverse effects on the development of hind limb long bone by disorder in the histology details of cell structure and growth into long bone during endochondral ossification, and may cause severe adverse alterations in rat fetus.
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