Effects of VIP in the female genital tract.

Abstract

Vasoactive Intestinal Polypeptide (VIP) has been demonstrated in the female genitourinary tract, localized in neurons which seem to innervate vessels and non-vascular smooth muscle. The present work has demonstrated that the concentration of immunoreactive VIP varies between different mammalian species and within the genital tract of the same species. Using various in vivo and in vitro preparations the peptide was found to have a dose-dependent inhibitory effect on the myoelectrical activity and contractility of the uterine muscle, and to increase myometrial blood flow. The findings support the hypothesis that VIP may play a physiological role in the local control of uterine motility and blood flow.

Statistics

0200040006000'88'91'94'97'00'03'06'09'12'15
Citations per Year

625 Citations

Semantic Scholar estimates that this publication has 625 citations based on the available data.

See our FAQ for additional information.

Cite this paper

@article{Ottesen1980EffectsOV, title={Effects of VIP in the female genital tract.}, author={Bent S. Ottesen and Jan Fahrenkrug and Gorm Wagner and Heather Ulrichsen and N Einer-jensen and Anthony M Carter and Jens J\orgen Larsen and Bent Stolberg}, journal={Endocrinologia japonica}, year={1980}, volume={27 Suppl 1}, pages={71-8} }