Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.

@article{Nieuwkerk1996EffectsOU,
  title={Effects of Ursodeoxycholate and cholate feeding on liver disease in FVB mice with a disrupted mdr2 P-glycoprotein gene.},
  author={Carin M. J. van Nieuwkerk and Ronald P. J. Oude Elferink and Albert K. Groen and Roelof Ottenhoff and Guido N. J. Tytgat and Koert P. Dingemans and Marius A. van den Bergh Weerman and G. Johan A. Offerhaus},
  journal={Gastroenterology},
  year={1996},
  volume={111 1},
  pages={165-71}
}
BACKGROUND & AIMS The mouse mdr2 gene encodes a P-glycoprotein expressed in the hepatocanalicular membrane. Inactivation of this gene causes lack of biliary phospholipid and cholesterol secretion and non-suppurative cholangitis. The aim of this study was to investigate the role of bile salt hydrophobicity in induction of liver pathology in mdr2 (-/-) mice. METHODS Mice (+/+) wild type or (-/-) knockout for the mdr2 gene were fed with either purified control diet or this diet supplemented with… CONTINUE READING
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