Effects of Uncaria tomentosa Total Alkaloid and its Components on Experimental Amnesia in Mice: Elucidation Using the Passive Avoidance Test

@article{Mohamed2000EffectsOU,
  title={Effects of Uncaria tomentosa Total Alkaloid and its Components on Experimental Amnesia in Mice: Elucidation Using the Passive Avoidance Test},
  author={Ahmed F. Mohamed and Kinzo Matsumoto and K Tabata and Hiromitsu Takayama and M Kitajima and H Y Watanabe},
  journal={Journal of Pharmacy and Pharmacology},
  year={2000},
  volume={52}
}
The effects of Uncaria tomentosa total alkaloid and its oxindole alkaloid components, uncarine E, uncarine C, mitraphylline, rhynchophylline and isorhynchophylline, on the impairment of retention performance caused by amnesic drugs were investigated using a step‐down‐type passive avoidance test in mice. In this test, the retention performance of animals treated with the amnesic and test drugs before training was assessed 24 h after training. 
Anxiogenic-like effects of Uncaria tomentosa (Willd.) DC. aqueous extract in an elevated plus maze test in mice: a preliminary study
TLDR
UTE revealed an anxiogenic effect in relation to the control group at 15 and 30 days, but it was reversed after 90 days of administration, without affecting the locomotor activity or any deleterious effects on the overall performance of the animal, either for its ambulation, or clinical status, and body weight and organ weight/body weight from liver, lung and kidney were unaffected.
Phellodendron amurense and Its Major Alkaloid Compound, Berberine Ameliorates Scopolamine-Induced Neuronal Impairment and Memory Dysfunction in Rats
  • Bombi Lee, B. Sur, I. Shim, Hye-jeong Lee, D. Hahm
  • Biology, Psychology
    The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology
  • 2012
TLDR
It is suggested that PA and BER may be useful as therapeutic agents for improving cognitive functioning by stimulating cholinergic enzyme activity and alleviating inflammatory responses.
Pharmacologyonline 2 : 197-214 ( 2008 ) Newsletter Potawale
TLDR
Uncaria tomentosa inner bark extract is a popular plant remedy used in folk medicine to treat tumor and anti-inflammatory process, and the ethnomedicinal uses are as an antioxidant, has antiapoptic properties and can enhance DNA repair.
Advances in chemistry and bioactivity of the genus Uncaria
  • G. Laus
  • Chemistry
    Phytotherapy research : PTR
  • 2004
The alkaloids of the pantropical genus Uncaria (Rubiaceae) were reviewed extensively by Phillipson et al. in (1978) Since then a host of papers with new results has been published. The compounds
Effect of Scutellaria Baicalensis on Scopolamine-Induced Memory and Cognitive Impairment in Rats
TLDR
PTW had a significants neuroprotective effect caused by β-amyloid in rats, suggesting that PTW may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.
Rehmannia glutinosa ameliorates scopolamine-induced learning and memory impairment in rats.
TLDR
The results suggest that SRG may be useful for improving cognitive functioning by stimulating cholinergic enzyme activities and alleviating inflammatory responses.
Protective effect of Phellodendri Cortex against lipopolysaccharide-induced memory impairment in rats
TLDR
It is suggested that PCE may be effective in preventing or slowing the development of neurological disorders, including Alzheimer's disease, by improving cognitive and memory function because of its anti-inflammation activity in the brain.
...
...

References

SHOWING 1-10 OF 38 REFERENCES
Die Alkaloide von Uncaria tomentosa und ihre Phagozytose-steigernde Wirkung.
TLDR
With the exception of mitraphyllin and rynchophyllin all alkaloids showed a pronounced enhancement effect on phagozytosis, determined in two IN VITRO tests and the IN VIVO-carbon clearance test.
Uncaria tomentosa (Willd.) D.C.: cat's claw, uña de gato, or savéntaro.
  • K. Reinhard
  • Chemistry
    Journal of alternative and complementary medicine
  • 1999
TLDR
It was found that 2 chemotypes of Uncaria tomentosa with different alkaloid patterns occur in nature, and Mixtures of these 2 types of drugs are therefore unsuitable for medicinal uses.
Alkaloids from S. American species of Uncaria (Rubiaceae)
TLDR
The morphological and chemical affinities between the different geographical groups of species are of interest in the light of divergent theories as to the origin of the Asian, African and S. American continents.
Scopolamine amnesia of passive avoidance: a deficit of information acquisition.
  • D. Rush
  • Biology, Psychology
    Behavioral and neural biology
  • 1988
Antiinflammatory actions of cat’s claw: the role of NF‐κB
Uncaria tomentosa is a vine commonly known as cat’s claw or ‘uña de gato’ (UG) and is used in traditional Peruvian medicine for the treatment of a wide range of health problems, particularly
Effects of U-50,488H on scopolamine-, mecamylamine- and dizocilpine-induced learning and memory impairment in rats.
TLDR
U-50,488H reverses the impairment of learning and memory induced by the blockade of cholinergic transmission and abolishes the decrease of acetylcholine release induced by mecamylamine via the kappa receptor-mediated opioid neuronal system.
...
...