• Corpus ID: 54791496

Effects of Ubiquinol in Reducing the Development of Heart Failurewith Preserved Ejection Fraction and Mitochondrial Injury

  title={Effects of Ubiquinol in Reducing the Development of Heart Failurewith Preserved Ejection Fraction and Mitochondrial Injury},
  author={Qiuhua Shen and John B. Hiebert and Amanda R Thimmesch and Richard L. Clancy and Janet D. Pierce},
  journal={Research and reviews: journal of nursing and health sciences},
  • Q. Shen, J. Hiebert, J. Pierce
  • Published 27 June 2016
  • Biology
  • Research and reviews: journal of nursing and health sciences
There is currently no effective clinical treatment for diastolic heart failure also termed heart failure with preserved ejection fraction (HFpEF) which is associated with reduced myocardial adenosine triphosphate. Ubiquinol in the electron chain is required for adenosine triphosphate synthesis. Thus, the purpose of this pilot study was to examine in a rat model the effects of ubiquinol (reduced form of Coenzyme Q10) in the development of HFpEF. Six Dahl salt-sensitive rats were randomly… 

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