Effects of UTP on membrane current and potential in rat aortic myocytes.

@article{Muraki1998EffectsOU,
  title={Effects of UTP on membrane current and potential in rat aortic myocytes.},
  author={Katsuhiko Muraki and Yuji Imaizumi and Masaru Watanabe},
  journal={European journal of pharmacology},
  year={1998},
  volume={360 2-3},
  pages={239-47}
}
The electrophysiological effects of UTP on freshly isolated rat aortic myocytes were examined using the perforated patch clamp technique. Application of alpha,beta-methylene ATP (alphabeta-meATP) and UTP, putative P2X and P2Y2 or P2Y4 purinoceptor agonists, induced transient and oscillatory inward currents, respectively. Experiments with Cl- channel blockers and different external Cl- concentrations demonstrated that the oscillatory current elicited by UTP is attributable to activation of Cl… CONTINUE READING