Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine.

@article{Wang2016EffectsOU,
  title={Effects of UGT2B7 Genetic Polymorphisms on Serum Concentrations of Valproic Acid in Chinese Children With Epilepsy Comedicated With Lamotrigine.},
  author={Qiuning Wang and Limei Zhao and M. -Z. Liang and Yang Dong and Wenting Yun and Feng Qiu and Homgmei Meng and Yingjie Guo},
  journal={Therapeutic drug monitoring},
  year={2016},
  volume={38 3},
  pages={343-9}
}
BACKGROUND Valproic acid (VPA) is widely used in the treatment of children with epilepsy. Genetic polymorphisms in genes encoding drug-metabolizing enzymes may be an important source of interindividual variability in VPA metabolism. VPA is a substrate of uridine diphosphate glucuronosyltransferase 2B7 (UGT2B7). In this study, we seek to evaluate the effects of genetic polymorphisms of the UGT2B7 gene on serum VPA concentrations in epileptic children comedicated with lamotrigine (LTG). METHODS… CONTINUE READING
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