Effects of UCMS-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater.

@article{Zhang2013EffectsOU,
  title={Effects of UCMS-induced depression on nociceptive behaviors induced by electrical stimulation of the dura mater.},
  author={Mingjie Zhang and Wei Dai and Jingyao Liang and Xiaoyan Chen and Yueqing Hu and Bingqian Chu and Meiyan Pan and Zhao Dong and Shengyuan Yu},
  journal={Neuroscience letters},
  year={2013},
  volume={551},
  pages={1-6}
}
The comorbidity between migraine and depression not only provides a major treatment challenge, but also represents a heavy burden on society. However, the relationship between depression and migraine and their molecular biological mechanisms remain unclear. This study investigated the effects of depression elicited by unpredictable chronic mild stress (UCMS) on trigeminovascular nociception in conscious rats and detected a concentration of calcitonin gene-related peptide (CGRP) and substance P… CONTINUE READING
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