Effects of Tyrosine, Phentermine, Caffeine d-amphetamine, and Placebo on Cognitive and Motor Performance Deficits During Sleep Deprivation

  title={Effects of Tyrosine, Phentermine, Caffeine d-amphetamine, and Placebo on Cognitive and Motor Performance Deficits During Sleep Deprivation},
  author={Richard A. Magill and William F. Waters and George A Bray and Julia Volaufova and Steven R Smith and Harris R. Lieberman and Nancy McNevin and Donna H. Ryan},
  journal={Nutritional Neuroscience},
  pages={237 - 246}
Abstract Cognitive and motor performance are critical in many circumstances and are impaired by sleep deprivation. We administered placebo, tyrosine 150 mg/kg, caffeine 300 mg/70 kg, phentermine 37.5 mg and d-amphetamine 20 mg at 15.30 h following overnight sleep deprivation and compare their effects on cognitive and motor performance in healthy young men. Tests of visual scanning, running memory, logical reasoning, mathematical processing, the Stroop task, four-choice serial reaction time… 
Performance and alertness effects of caffeine, dextroamphetamine, and modafinil during sleep deprivation
At the doses tested, caffeine, dextroamphetamine, and modafinil are equally effective for approximately 2–4 h in restoring simple psychomotor performance and objective alertness.
The acute effects of d-amphetamine and methamphetamine on attention and psychomotor performance
The current series of studies primarily provides evidence of low-level amphetamines-related enhancement of function; however, it also providesevidence of less conservative movement estimation that might contribute to amphetamine-related road fatalities.
Effects of d-amphetamine on simulated driving performance before and after sleep deprivation
The results suggest that administration of d-amphetamine does not compensate for impairment of driving due to fatigue, and there are no interactions between dose and sleep deprivation for any of the performance indicators.
Impact of Various Caffeine Vehicles on Mood and Cognitive, Neurological and Physiological Functions over Five Hours
The 5-Hour Energy group rated alertness higher than other caffeine treatments, and was the only group to demonstrate decreases in alpha waves, memory improvements, and impaired glucose homeostasis.
Effects of caffeine on visual evoked potential (P300) and neuromotor performance.
The findings suggest that the positive tendency of caffeine to improve cognitive performance is probably associated with changes in the frontal cortex, a widely recognized attention area.
Sleep Deprivation and Time-Based Prospective Memory.
The results highlight the potential dangerous effects of total sleep deprivation on human behavior, particularly the ability to perform an intended action after a few minutes, and sleep deprivation strongly compromises time-based prospective memory compliance but does not affect time check frequency.
A single dose of the catecholamine precursor Tyrosine reduces physiological arousal and decreases decision thresholds in reinforcement learning and temporal discounting
Supplementation with the catecholamine precursor L-Tyrosine might enhance cognitive performance, but overall findings are mixed. Here, we investigate the effect of a single dose of tyrosine (2g) vs.


The effects of d-amphetamine on arousal, cognition, and mood after prolonged total sleep deprivation.
Modafinil, d‐amphetamine and placebo during 64 hours of sustained mental work. I. Effects on mood, fatigue, cognitive performance and body temperature
Modafinil appears to be a good alternative to amphetamine for counteracting the debilitating mood and cognitive effects of sleep loss during sustained operations.
Stimulant Drug Effects on Performance and Behavior After Prolonged Sleep Deprivation: A Comparison of Amphetamine, Nicotine, and Deprenyl
It is concluded that nicotine nor I-deprenyl produced substantial persistent reversal of sleep deprivation effects, and amphetamine is unlikely to be useful for the acute remediation of the effects of severe sleep loss.
The effects of tyrosine on cognitive performance during extended wakefulness.
Tyrosine administration was associated with a significant amelioration of the usual performance decline on a psychomotor task and a significant reduction in lapse probability on a high-event-rate vigilance task, suggesting that tyrosine is a relatively benign treatment at this dose.
Slow release caffeine and prolonged (64‐h) continuous wakefulness: effects on vigilance and cognitive performance
It was shown that 300‐mg SRC given twice daily during a 64‐h SD is able to antagonize the impairment produced on vigilance and cognitive functions.
Slow-release caffeine: a new response to the effects of a limited sleep deprivation.
SR caffeine (300 mg) seems to be an efficient and safety substance to maintain a good level of vigilance and performance during limited sleep deprivation.
Caffeine reversal of sleep deprivation effects on alertness and mood
Caffeine was able to produce significant alerting and long-lasting beneficial mood effects in individuals deprived of sleep for 48 h and produced values close to fully rested conditions on several VAS.
Effect of three caffeine doses on plasma catecholamines and alertness during prolonged wakefulness
High doses of caffeine have a significant and beneficial effect on alertness during prolonged wakefulness, and responses to sleep latency, sleepiness scores, and reaction time scores showed dose-related changes that were exhibited by significant correlation coefficients.
Slow‐release caffeine as a countermeasure to driver sleepiness induced by partial sleep deprivation
It is suggested that a lack of sleep can lead to a significant driving performance impairment, with drivers having problems to maintain an appropriate road position and a posted speed and more drivers getting involved in an accident and caffeine can serve as a valuable countermeasure to these performance decrements.
Maintaining alertness and performance during sleep deprivation: modafinil versus caffeine
Performance and alertness were significantly improved by modafinil 200 and 400 mg relative to placebo, and effects were comparable to those obtained with caffeine 600 mg, although a trend toward better performance at higher modaf inil doses suggested a dose-dependent effect.