Effects of Tumor Necrosis Factor Alpha Antagonist, Platelet Activating Factor Antagonist, and Nitric Oxide Synthase Inhibitor on Experimental Otitis Media with Effusion

@article{Kim2006EffectsOT,
  title={Effects of Tumor Necrosis Factor Alpha Antagonist, Platelet Activating Factor Antagonist, and Nitric Oxide Synthase Inhibitor on Experimental Otitis Media with Effusion},
  author={Dong-Hyun Kim and Yong-Soo Park and E. Jeon and S. Yeo and Ki-Hong Chang and S. K. Lee},
  journal={Annals of Otology, Rhinology \& Laryngology},
  year={2006},
  volume={115},
  pages={617 - 623}
}
Objectives: We studied the inflammatory responses in otitis media with effusion induced by lipopolysaccharide (LPS) in rats, and compared the preventive effects of tumor necrosis factor (TNF) soluble receptor type I (sTNFRI, a TNF-α antagonist), platelet activating factor antagonist, and the nitric oxide synthase inhibitor N(G)-nitro-l-arginine methyl ester (l-NAME). Methods: We used 2 control groups of Sprague Dawley rats (untreated and saline-treated) and 4 experimental groups, which all… Expand
Effects of a Tumor Necrosis Factor-α Antagonist on Experimentally Induced Rhinosinusitis
TLDR
It is shown that sTNFRI reduces inflammatory activity and mucus hypersecretion in LPS-induced rhinosinusitis in rats. Expand
Expressions of cyclooxygenase 1 and 2 in endotoxin-induced otitis media with effusion in the rat.
TLDR
The findings indicate that COX-2 inhibitor administration for the relief of inflammation should be considered within 12h of the initiation of an inflammatory process, and may provide an understanding of the mechanisms regulating PG formation in infection of the middle ear cavity. Expand
Effects of glucocorticoids on lipopolysaccharide-induced inflammatory responses in human middle ear epithelial cells and its mechanisms
This study aimed to investigate the effects and mechanisms of glucocorticoids on lipopolysaccharide (LPS)-induced inflammatory responses in human middle ear epithelial cells (HMEECs). HMEECs wereExpand
The suppressive effects of metformin on inflammatory response of otitis media model in human middle ear epithelial cells.
TLDR
It is suggested that the inflammatory response and oxidative stress induced by LPS could be suppressed by metformin in HMEECs and may have a therapeutic potential for the treatment of the otitis media. Expand
Inhibitory effect of caffeic acid phenethyl ester (CAPE) on LPS-induced inflammation of human middle ear epithelial cells
Conclusions. The results suggest that the anti-inflammatory effect of caffeic acid phenethyl ester (CAPE) is due to its inhibition of tumor necrosis factor (TNF)-α expression and interleukin (IL)-8Expand
Soluble TNFR II/IgG1 Fc fusion protein treatment in the LPS-mediated septic shock of rats.
TLDR
Results indicate that TNF-alpha is a mediator of fatal septic shock, and suggest that sTNFR:Fc offer a potential therapy of systemic infection. Expand
The preventive effect of N-nitro L-arginine methyl ester in experimentally induced myringosclerosis.
TLDR
The results showed that both topical and intraperitoneal applications of L-NAME supressed inflammation, reduced fibroblastic proliferation and decreased the formation of myringosclerosis in myringotomized rat tympanic membranes. Expand
Effect of Infliximab on Experimentally Induced Otitis Media in Rats
TLDR
It is suggested that the monoclonal tumor necrosis factor α antibody, infliximab, can reduce inflammatory activity in experimental otitis media in rats. Expand
CC Chemokine Ligand 3 Overcomes the Bacteriocidal and Phagocytic Defect of Macrophages and Hastens Recovery from Experimental Otitis Media in TNF−/− Mice
TLDR
CCL3 is a potent downstream effector of TNF-mediated inflammation in vitro and in vivo, and Manipulation of CCL3 and/or TNF may prove to be effective therapeutic approaches in OM or other conditions associated with defective TNF generation. Expand
Quantification of the mRNA encoding Tumor Necrosis Factor α ( TNFα ) and its receptors in human nasal polyps
Purpose: The object of the study was to assess the expression of the genes encoding TNFα and its receptors (TNF-R1 and TNF-R2) in patients with nasal polyps (NP). Material and methods: The number ofExpand
...
1
2
...

References

SHOWING 1-10 OF 18 REFERENCES
Effect of Inhibitor of Tumor Necrosis Factor-Alpha on Experimental Otitis Media with Effusion
TLDR
It is suggested that TNF-α antagonist, along with antibiotics, may have an adjunctive role in the future treatment of MEE, as it appears to suppress the development of LPS-induced OME. Expand
Effect of 10 Pharmacologic Probes on mRNA Levels of Inducible Nitric Oxide Synthetase and Selected Inflammatory Cytokines in a Rat Model of Acute Otitis Media
TLDR
Results show that pharmacological agents can modify the expression of inflammatory mediators in this model of acute otitis media caused by Streptococcus pneumoniae and may have clinically relevant effects. Expand
Role of Tumor Necrosis Factor and Interleukin-1 in Endotoxin-Induced Middle Ear Effusions
TLDR
It is indicated that TNF, but not IL-1, is a mediator of LPS-induced MEEs and TNFbp may represent a novel approach to the treatment of otitis media with effusion. Expand
Effect of Web 2170 BS, Platelet Activating Factor Receptor Inhibitor, in the Guinea PIG Model of Middle Ear Inflammation
TLDR
It is demonstrated that WEB 2170 BS can produce significant anti-inflammatory effects in this model of OM induced by middle ear (ME) inoculation of killed Staphylococcus aureus. Expand
Effect of tumor necrosis factor-alpha on experimental otitis media with effusion.
TLDR
Neutrophil infiltration, subepithelial edema, increased microvascular permeability, and resultant effusion were indirectly proved to be induced by tumor necrosis factor-alpha. Expand
Cytokine expression in otitis media with effusion. Tumor necrosis factor soluble receptor.
TLDR
The hypothesis that cytokines and their inhibitors are present in a large number of middle ear effusions and in part are likely important in the regulation of inflammatory processes in COME is supported. Expand
Nitric Oxide Mediates Mucin Secretion in Endotoxin-Induced Otitis Media with Effusion
The mechanisms that regulate mucin release in chronic otitis media with effusion, a leading cause of hearing loss in children, remain largely unknown. We developed an animal model usingExpand
Experimental Otitis Media with Effusion Induced by Platelet Activating Factor
TLDR
PAF injected into the middle ear can induce OME and that PAF antagonists effectively prevent PAF-induced OME are demonstrated, suggesting that PAf plays an important role in the pathogenesis of OME. Expand
Immunologic Characteristics of Cytokines in Otitis Media with Effusion
TLDR
It is shown that cytokines, especially IL-1β, contribute to infiltration into the middle ear by inflammatory cells, which implies that the persistent presence of cytokines in MEE could be a factor in prolonged OME. Expand
Characterization of cytokines present in middle ear effusions
TLDR
The presence of six cytokines in middle ear effusions from children with COME may be responsible for the mucosal damage, bone erosion, fibrosis, and resulting hearing loss seen in some cases of COME. Expand
...
1
2
...