Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans

@article{PraschakRieder2005EffectsOT,
  title={Effects of Tryptophan Depletion on the Serotonin Transporter in Healthy Humans},
  author={Nicole Praschak-Rieder and Alan A. Wilson and Douglas F Hussey and Anna Carella and Corie Wei and Nathalie Ginovart and Markus J. Schwarz and Johanna Zach and Sylvain Houle and Jeffrey H. Meyer},
  journal={Biological Psychiatry},
  year={2005},
  volume={58},
  pages={825-830}
}
BACKGROUND Lowering of brain serotonin by acute tryptophan depletion (TD) frequently leads to transient symptoms of depression in vulnerable individuals but not in euthymic healthy subjects with a negative family history of depression. The effects of TD on regional serotonin transporter binding potential (5-HTT BP), an index of 5-HTT density and affinity, were studied in healthy individuals using 3-(11)C-amino-4-(2-dimethylaminomethylphenylsulfanyl)benzonitrile ([11C]DASB) positron emission… CONTINUE READING
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