Effects of Transdermal Estrogen Replacement Therapy on Cardiovascular Risk Factors

  title={Effects of Transdermal Estrogen Replacement Therapy on Cardiovascular Risk Factors},
  author={Dileep V. Menon and Wanpen Vongpatanasin},
  journal={Treatments in Endocrinology},
The prevalence of hypertension and cardiovascular disease increases dramatically after menopause in women, implicating estrogen as having a protective role in the cardiovascular system. However, recent large clinical trials have failed to show cardiovascular benefit, and have even demonstrated possible harmful effects, of opposed and unopposed estrogen in postmenopausal women. While these findings have led to a revision of guidelines such that they discourage the use of estrogen for primary or… 

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This article is a review of the major research studies of HRT in postmenopausal women with respect to its safety and efficacy for the primary prevention of cardiovascular disease.

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Cyclic, short term exposure to vaginal micronized progesterone did not alter the metabolic and cardiovascular effects of non-oral E2 in early, apparently healthy, postmenopausal women.

Hormonal replacement therapy (HRT) in postmenopause: a reappraisal.

  • A. Caufriez
  • Medicine, Biology
    Annales d'endocrinologie
  • 2007

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Bioidentical hormone therapy (BHT) uses bioidentical hormones (BHs), derivatives of plant extracts chemically modified to be structurally indistinguishable from human endogenous hormones. BHTs are

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Different effects of oral and transdermal estrogen replacement therapy on matrix metalloproteinase and their inhibitor in postmenopausal women.

To the Editor: The Heart and Estrogen/Progestin Replacement Study1 and the Women’s Health Initiative2 showed no benefit of oral hormone replacement therapy (HRT) on the risk of coronary heart

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In normotensive postmenopausal women, chronic transdermal ERT decreases SND without augmenting arterial baroreflexes and causes a small but statistically significant decrease in ambulatory BP.

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Oral estrogen/progesterone replacement therapy may result in coagulation activation and increased fibrinolytic potential, whereas opposed transdermal estrogen appears without any substantial effects on hemostasis.

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