Effects of Toxins Pi2 and Pi3 on Human T Lymphocyte Kv1.3 Channels: The Role of Glu7 and Lys24

@article{Peter2001EffectsOT,
  title={Effects of Toxins Pi2 and Pi3 on Human T Lymphocyte Kv1.3 Channels: The Role of Glu7 and Lys24},
  author={Matthias Peter and Zs Varga and P{\'e}ter Hajd{\'u} and Rezs{\"o} G{\'a}sp{\'a}r and S{\'a}ndor Damjanovich and Eduardo Horjales and Lourival Domingos Possani and Gy{\"o}rgy Panyi},
  journal={The Journal of Membrane Biology},
  year={2001},
  volume={179},
  pages={13-25}
}
Pandinus imperator scorpion toxins Pi2 and Pi3 differ only by a single amino acid residue (neutral Pro7 in Pi2 vs. acidic Glu7 in Pi3). The binding kinetics of these toxins to human Kv1.3 showed that the decreased on rate (k ON = 2.18 × 108 m −1sec−1 for Pi2 and 1.28 × 107 m −1sec−1 for Pi3) was almost entirely responsible for the increased dissociation constant (K d ) of Pi3 (K d = 795 pm) as compared to Pi2 (K d = 44 pm). The ionic strength dependence of the association rates was exactly the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-10 of 14 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 40 references

Structure and function of scorpion toxins affecting K + channels.Perspectives in drug discovery and design

  • L. D. Possani, B. Selisko, G. Gurrola Briones
  • 1999
1 Excerpt

Structure and function of scorpion toxins affecting K + channels

  • L. D. Possani, B. Selisko, G. Gurrola Briones
  • Perspectives in drug discovery and design
  • 1999

Novel scorpion K channel toxins isolated from venoms of species belonging to the Parabuthusgenus.Biophys

  • J. Tytgat, T. Debont, +6 authors J. J. van der Walt
  • 1998
2 Excerpts

Similar Papers

Loading similar papers…