Effects of Thyroid Hormone and Hypoxia on 2,3-Bisphosphoglycerate, Bisphosphoglycerate Synthase and Phosphoglycerate Mutase in Rabbit Erythroblasts and Reticulocytes in vivo

@article{GonzlezCinca2004EffectsOT,
  title={Effects of Thyroid Hormone and Hypoxia on 2,3-Bisphosphoglycerate, Bisphosphoglycerate Synthase and Phosphoglycerate Mutase in Rabbit Erythroblasts and Reticulocytes in vivo},
  author={N{\'u}ria Gonz{\'a}lez-Cinca and Pablo P{\'e}rez de la Ossa and Jos{\'e} Carreras and Fernando Climent},
  journal={Hormone Research in Paediatrics},
  year={2004},
  volume={62},
  pages={191 - 196}
}
Objectives: The effects of triiodothyronine (T3) and hypoxia on 2,3-bisphosphoglycerate (2,3-BPG) studied in vitro are unclear. To clarify these effects we selected a more physiologic approach: the in vivo study in rabbits. We also present the changes produced by T3 and hypoxia on phosphoglycerate mutase (PGAM), which requires 2,3-BPG as a cofactor, and 2,3-BPG synthase (BPGS), the enzyme responsible for 2,3-BPG synthesis in erythroblasts and reticulocytes. Methods: Hyperthyroidism was induced… 

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