Effects of Tesamorelin, a Growth Hormone–Releasing Factor, in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial With a Safety Extension

@article{Falutz2010EffectsOT,
  title={Effects of Tesamorelin, a Growth Hormone–Releasing Factor, in HIV-Infected Patients With Abdominal Fat Accumulation: A Randomized Placebo-Controlled Trial With a Safety Extension},
  author={J. Falutz and D. Potvin and J. Mamputu and H. Assaad and M. Zoltowska and Sophie-Elise Michaud and D. Berger and M. Somero and G. Moyle and Stephen Brown and C. Martorell and Ralph Turner and S. Grinspoon},
  journal={JAIDS Journal of Acquired Immune Deficiency Syndromes},
  year={2010},
  volume={53},
  pages={311-322}
}
Background:HIV-infected patients receiving antiretroviral therapy often demonstrate excess visceral fat. A growth hormone-releasing factor, tesamorelin, may selectively reduce visceral fat in this population. We investigated the effects of tesamorelin (GHRH1-44) in HIV-infected patients with central fat accumulation. Methods:A 12-month study of 404 HIV-infected patients with excess abdominal fat in the context of antiretroviral therapy was conducted between January 2007 and October 2008. The… Expand
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