Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis

  title={Effects of Taurine Supplementation on Growth in Low Birth Weight Infants: A Systematic Review and Meta-Analysis},
  author={Shun-li Cao and Hong Jiang and Shi-ping Niu and Xiaohu Wang and Shan Du},
  journal={The Indian Journal of Pediatrics},
ObjectiveTo summarize the available randomized controlled trials (RCTs) to evaluate the effect of taurine supplementation on growth in low birth weight infants (LBW).MethodsPubMed, EmBase, and Cochrane Library electronic databases were searched for published articles through March 2017. Analysis was done to examine the effect of taurine supplementation on growth, and sensitivity analysis was performed by removing each individual study from meta-analysis.ResultsResults of 9 trials totaling 216… 
The effect of milk type and fortification on the growth of low‐birthweight infants: An umbrella review of systematic reviews and meta‐analyses
A systematic review in PubMed, CINAHL, Embase and Web of Science comparing infant milk options and growth found evidence of improved growth when protein is added to both human milk and formula.
Bioactive Compounds in Infant Formula and Their Effects on Infant Nutrition and Health: A Systematic Literature Review
Assessment of the scientific evidence of bioactive compounds present in infant formulas (α-lactalbumin, lactoferrin, taurine, milk fat globule membrane, folates, polyamines, long-chain polyunsaturated fatty acids, prebiotics, and probiotics) and their effects on infant nutrition and health.
Taurine and Neonatal Nutrition
  • D. Chawla
  • Medicine
    The Indian Journal of Pediatrics
  • 2018
No clinically beneficial effect of taurine supplementation was observed on short-term physical growth of neonates and none of the studies have reported long-term effects on the neurodevelopment.
Metabolomics Applied to Cord Serum in Preeclampsia Newborns: Implications for Neonatal Outcomes
The abundance of metabolites related to certain amino acid, sphingolipid, and energy metabolism increased in the umbilical cord serum of PE neonates, and Taurine-related metabolism and ketone body-related pathways were mainly affected.
The need to study human milk as a biological system
The rationale and critical need for unveiling the multifunctionality of the various nutritional, nonnutritional, immune, and biological signaling pathways of the components in human milk that drive system development and maturation, growth, and development in the very early postnatal period of life are described.
Preterm birth and human milk proteome: are we ready for individualized fortification?
Purpose of review Preterm birth is one of the most pressing clinical problems in obstetrics and neonatology worldwide. One of the most sophisticated components of human milk is the proteome and a


Effect of taurine supplementation on growth and development in preterm or low birth weight infants.
A meta-analyses did not reveal any statistically significant effects on growth parameters assessed during the neonatal period or until three to four months chronological age, and it is likely that taurine will continue to be added to formula milks and parenteral nutrition solutions used for feeding preterm and low birth weight infants given the putative association of taurin deficiency with various adverse outcomes.
Effect of Taurine Supplementation on Hepatic Function During Short‐Term Parenteral Nutrition in the Premature Infant
The results indicate the rapid maturation of hepatic function even in the presence of parenteral nutrition during the first 10 days of life, indicating the potential role of taurine deficiency in the pathogenesis of p Karenteral Nutrition-induced cholestasis.
Randomized Trial of Taurine Supplementation for Infants \g=le\1,300-Gram Birth Weight: Effect on Auditory Brainstem-Evoked Responses
Taurine intake appears to influence auditory system maturation of preterm infants, and infants who received taurine supplementation had greater overall plasma t aurine concentrations.
Influence of dietary taurine on vitamin D absorption
Low taurine dietary intake appears to compromise vitamin D absorption in preterm infants, and therefore taurin supplementation of preterm infant formulas should be encouraged.
Taurine Supplementation of a Premature Formula Improves Fat Absorption in Preterm Infants
Data show that the addition of Tau to formula had no effect on growth but improved the absorption of fat especially saturated fatty acids which require higher concentrations of bile acids to form mixed micelles.
Effect of taurine on synthesis of neutral and acidic sterols and fat absorption in preterm and full-term infants.
Only in preterm infants appropriate for GA and small for GA with a mean GA < 33 wk, did taurine supplementation result in lower cholesterol synthesis and higher bile acid excretion and fatty acid absorption.
Vitamin A supplementation to prevent mortality and short- and long-term morbidity in very low birth weight infants.
Whether clinicians decide to utilise repeat intramuscular doses of vitamin A to prevent chronic lung disease may depend upon the local incidence of this outcome and the value attached to achieving a modest reduction in the outcome balanced against the lack of other proven benefits and the acceptability of the treatment.
Randomized trial of taurine supplementation for infants less than or equal to 1,300-gram birth weight: effect on auditory brainstem-evoked responses.
Taurine intake appears to influence auditory system maturation of preterm infants, and group receiving taurine supplementation had more mature auditory-evoked responses at 37 weeks' postmenstrual age.
Higher versus lower protein intake in formula-fed low birth weight infants.
The overall analysis revealed an improved weight gain and higher nitrogen accretion in infants receiving formula with higher protein content while other nutrients were kept constant, and improved growth and neurodevelopmental outcomes without evidence of short and long-term morbidity.