Effects of Tatariside G Isolated from Fagopyrum tataricum Roots on Apoptosis in Human Cervical Cancer HeLa Cells

  title={Effects of Tatariside G Isolated from Fagopyrum tataricum Roots on Apoptosis in Human Cervical Cancer HeLa Cells},
  author={Yuan Li and Su-Juan Wang and Wei Xia and Khalid Rahman and Yan Zhang and Hao Peng and Hong Zhang and Luping Qin},
  pages={11145 - 11159}
Cervical cancer is the second most common female carcinoma. Current therapies are often unsatisfactory, especially for advanced stage patients. The aim of this study was to explore the effects of tatariside G (TG) on apoptosis in human cervical cancer HeLa cells and the possible mechanism of action involved. An MTT assay was employed to evaluate cell viability. Hoechst 33258 staining and flow cytometry (FCM) assays were used to detect cell apoptosis. The protein expression of phosphorylated JNK… 

Figures and Tables from this paper

Molecular mechanisms of ampelopsin from Ampelopsis megalophylla induces apoptosis in HeLa cells

Results indicate that AMP may induce apoptosis via the mitochondrial signaling pathway in HeLa cells through the activation of caspases 9 and 3 and the loss of mitochondrial transmembrane potential and the release of cytochrome c suggested thatAMP-induced apoptosis was associated with the mitochondrial pathway.

Cinnamaldehyde affects the biological behavior of human colorectal cancer cells and induces apoptosis via inhibition of the PI3K/Akt signaling pathway.

CA has the potential to be developed as a new antitumor drug through the regulation of expression of genes involved in apoptosis, invasion and adhesion via inhibition of the PI3K/Akt signaling pathway.

Anticancer and cytotoxic effects of troxerutin on HeLa cell line: an in-vitro model of cervical cancer

The study showed that 24 h of treatment with TRX has apoptotic and growth inhibitory effects against HeLa cells and can induce inflammation (at least via up-regulating the TNF-α protein expression) and oxidative stress in human He La cells.

The Cyr61 Is a Potential Target for Rotundifuran, a Natural Labdane-Type Diterpene from Vitex trifolia L., to Trigger Apoptosis of Cervical Cancer Cells

It is found that RTF can suppress the proliferation of cervical cancer cell lines, including HeLa and SiHa cells, via induction of apoptosis in vitro, and the antitumor effect of RTF is further confirmed on the HeLa cell-inoculated xenograft model.

Development of Certain Protein Kinase Inhibitors with the Components from Traditional Chinese Medicine

Several components isolated from anticancer TCMs that exhibited significantly inhibitory activity toward a range of protein kinases are reviewed, based upon the kinases that they inhibit.

Components from the Traditional Chinese Medicine Acts as Protein Kinase Inhibitors

This article comprehensively reviewed several components isolated from anticancer TCMs that exhibited significantly inhibitory activity towards a range of protein kinases, based upon the kinases that they inhibit.

Buckwheat as a Functional Food and Its Effects on Health.

Recent research regarding the health benefits of BW is reviewed, in vitro and in vivo, focusing on the specific role of its bioactive compounds and on the mechanisms by which these effects are exerted.

Recent discoveries of anticancer flavonoids.

Coevolution between Cancer Activities and Food Structure of Human Being from Southwest China

Yunnan and Tibet are the lowest cancer mortality and the largest producer for anticancer crops (brown rice, barley, buckwheat, tea, walnut, mushrooms, and so forth). Shanghai and Jiangsu province in




Cordyceps pruinosa extracts induce apoptosis of HeLa cells by a caspase dependent pathway.

Duchesnea Phenolic Fraction Inhibits In Vitro and In Vivo Growth of Cervical Cancer Through Induction of Apoptosis and Cell Cycle Arrest

Investigation of the anticancer effect and associated mechanisms of Duchesnea phenolic fraction on cervical cancer in vitro and in vivo showed that DPF significantly inhibited cervical cancer cell proliferation in dose- and time-dependent manners.

Homeopathic mother tincture of Phytolacca decandra induces apoptosis in skin melanoma cells by activating caspase-mediated signaling via reactive oxygen species elevation.

Overall results demonstrate anticancer potentials of PD on A375 cells through activation of caspase-mediated signaling and ROS generation.

Protective Effects of Polydatin from Polygonum cuspidatum against Carbon Tetrachloride-Induced Liver Injury in Mice

Results suggest that polydatin protects mice against CCl4-induced liver injury through antioxidant stress and antiinflammatory effects and may be an effective hepatoprotective agent and a promising candidate for the treatment of oxidative stress- and inflammation-related diseases.

Essential oil from rhizomes of Ligusticum chuanxiong induces apoptosis in hypertrophic scar fibroblasts

EO-induced apoptosis was at least partially carried out via destruction of the intracellular antioxidant system and elicitation of excessive ROS accumulation in HSFs, which impaired mitochondrial membranes and elicited caspase-3 activation.

Extract of buckwheat sprouts scavenges oxidation and inhibits pro-inflammatory mediators in lipopolysaccharide-stimulated macrophages (RAW264.7).

Buckwheat can be suggested to be beneficial in inflammatory diseases by inhibiting the free radicals and inflammatory mediators.