Effects of Tamoxifen and Toremifene on Urinary Excretion of Pyridinoline and Deoxypyridinoline and Bone Density in Postmenopausal Patients with Breast Cancer

@article{Marttunen1999EffectsOT,
  title={Effects of Tamoxifen and Toremifene on Urinary Excretion of Pyridinoline and Deoxypyridinoline and Bone Density in Postmenopausal Patients with Breast Cancer},
  author={M. Marttunen and P. Hietanen and A. Titinen and H. Roth and L. Viinikka and O. Ylikorkala},
  journal={Calcified Tissue International},
  year={1999},
  volume={65},
  pages={365-368}
}
Abstract. Tamoxifen and toremifene are two mostly used antiestrogens in the treatment of breast cancer. To compare their effect on bone in postmenopausal breast cancer patients we measured the urinary output of two bone resorption markers, pyridinoline (Pyr) and deoxypyridinoline (Dpyr) as well as bone density (BMD) in 30 breast cancer patients using either tamoxifen (20 mg/day, n = 15) or toremifene (40 mg/day, n = 15) as adjuvant treatment of stage II breast cancer for 1 year. The urinary… Expand
39 Citations
Effect of anastrozole on bone mineral density: 5-year results from the anastrozole, tamoxifen, alone or in combination trial 18233230.
  • R. Eastell, J. Adams, +6 authors G. Clack
  • Medicine
  • Journal of clinical oncology : official journal of the American Society of Clinical Oncology
  • 2008
  • 318
Effects of toremifene versus tamoxifen on breast cancer patients: a meta-analysis
  • 13
  • Highly Influenced
Pharmacokinetic evaluation of toremifene and its clinical implications for the treatment of osteoporosis
  • 9
The Effects of Tamoxifen and Toremifene on Bone Cells Involve Changes in Plasma Membrane Ion Conductance
  • P. Lehenkari, V. Parikka, +4 authors H. Väänänen
  • Biology, Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 2003
  • 26
...
1
2
3
4
...

References

SHOWING 1-10 OF 18 REFERENCES
Comparison of effects of tamoxifen and toremifene on bone biochemistry and bone mineral density in postmenopausal breast cancer patients.
  • 131
  • PDF
Effect of menopause and hormone replacement therapy on the urinary excretion of pyridinium cross-links.
  • 133
Comparison of new biochemical markers of bone turnover in late postmenopausal osteoporotic women in response to alendronate treatment.
  • 724
Urinary hydroxypyridinium crosslinks of collagen as markers of bone resorption and estrogen efficacy in postmenopausal osteoporosis
  • M. Seibel, F. Cosman, +4 authors R. Lindsay
  • Medicine
  • Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research
  • 1993
  • 150
  • Highly Influential
Different effects of bisphosphonate and estrogen therapy on free and peptide‐bound bone cross‐links excretion
  • 219
  • Highly Influential
Antiestrogenic Potency of Toremifene and Tamoxifen in Postmenopausal Women
  • 29
Bone turnover markers and bone density across the menopausal transition.
  • 143
...
1
2
...