Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study

@article{Uchiyama2022EffectsOT,
  title={Effects of TS-142, a novel dual orexin receptor antagonist, on sleep in patients with insomnia: a randomized, double-blind, placebo-controlled phase 2 study},
  author={Makoto Uchiyama and Daiji Kambe and Yumiko Imadera and Yu Kajiyama and Hiroki Ogo and Naohisa Uchimura},
  journal={Psychopharmacology},
  year={2022},
  volume={239},
  pages={2143 - 2154}
}
Novel compound with potent antagonistic activity against orexin receptors may be new treatment option for patients with insomnia. The aim was to investigate the efficacy and safety of single oral doses of the dual orexin receptor antagonist TS-142 in patients with insomnia. This multicenter, double-blind, crossover randomized clinical trial included non-elderly patients with insomnia. Patients were randomized to receive single doses of placebo and TS-142 at doses of 5, 10, and 30 mg in one of… 
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