Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.

@article{Wordinger2007EffectsOT,
  title={Effects of TGF-beta2, BMP-4, and gremlin in the trabecular meshwork: implications for glaucoma.},
  author={Robert J. Wordinger and Debra L Fleenor and Peggy E. Hellberg and I W Pang and Tara O Tovar and Gulab S. Zode and John A. Fuller and Abbot F. Clark},
  journal={Investigative ophthalmology & visual science},
  year={2007},
  volume={48 3},
  pages={1191-200}
}
PURPOSE The primary causative factor of primary open-angle glaucoma (POAG) is elevated intraocular pressure (IOP) due to increased aqueous humor (AH) outflow resistance, which is associated with morphologic and biochemical changes in the trabecular meshwork (TM). Patients with glaucoma have elevated levels of transforming growth factor (TGF)-beta2 in their AH, and TGF-beta has been shown to increase TM extracellular matrix (ECM) production. The bone morphogenetic protein (BMP) signaling pathway… CONTINUE READING

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