Effects of Synthetic Vasoactive Intestinal Peptide (VIP), Secretin and Their Partial Sequences on Gastric Secretion 1

  title={Effects of Synthetic Vasoactive Intestinal Peptide (VIP), Secretin and Their Partial Sequences on Gastric Secretion 1},
  author={G. Makhlouf and A. Zfass and S. Said and M. Schebalin},
  journal={Proceedings of the Society for Experimental Biology and Medicine},
  pages={565 - 568}
Summary The effects of synthetic porcine VIP and secretin on pentagastrin-stimulated gastric secretion were compared in dogs equipped with gastric fistulae. VIP inhibited both acid and pepsin secretion. Percent inhibition of acid secretion by VIP varied with the dose of pentagastrin: dose-response analysis showed inhibition to be of the competitive type. Percent inhibition of acid secretion by secretin did not vary with the dose of pentagastrin and was consistent with inhibition of the… Expand
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This study examined the effect of PACAP-27 on basal and pentagastrin (PG)-stimulated gastric acid secretion in conscious rats and compared its effect with that of VIP, and suggested that PACAP may have a regulatory role in gastric Acid secretion. Expand
Vasoactive intestinal peptide stimulates cyclic AMP metabolism in choroid plexus epithelial cells
Experiments measuring the cellular cyclic AMP accumulation in response to pairs of peptides suggested that vasointestinal peptide, porcine intestinal peptide and secretin act through a common receptor. Expand
Peptidergic Regulation of Gastric Acid Secretion
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