Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice

  title={Effects of Strain, Novelty, and NMDA Blockade on Auditory-Evoked Potentials in Mice},
  author={Steven J. Siegel and Patrick M. Connolly and Yuling Liang and Robert H. Lenox and Raquel E. Gur and Warren B. Bilker and Steven J Kanes and Bruce I. Turetsky},
People with schizophrenia exhibit impaired ability to modify electroencephalographic event-related potential (ERP) responses to novel stimuli. These deficits serve as a window into the abnormalities of neuronal organization and function and are thought to reflect a component of genetic vulnerability for schizophrenia. We describe differences among inbred mouse strains for ERPs following a novelty detection paradigm, as a model for genetic contributions to disease vulnerability. Auditory-evoked… CONTINUE READING


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