Effects of St. John's wort supplementation on ibuprofen pharmacokinetics.


BACKGROUND St. John's wort is a popular herbal supplement that has been involved in various herb-drug interactions. Experimental findings suggest that the supplement may impact CYP2C9 metabolism. CYP2C9 is responsible for the irreversible metabolism of ibuprofen. OBJECTIVE To examine the effect of 3 weeks of St. John's wort administration on the… (More)