Effects of Spider Venom Toxin PWTX-I (6-Hydroxytrypargine) on the Central Nervous System of Rats

  title={Effects of Spider Venom Toxin PWTX-I (6-Hydroxytrypargine) on the Central Nervous System of Rats},
  author={Lilian M M C{\'e}sar-Tognoli and Simone Denise Salamoni and Andr{\'e}a Alencar Tavares and Carol F. Elias and Jaderson Costa da Costa and Jackson Cioni Bittencourt and M{\'a}rio S{\'e}rgio Palma},
  pages={142 - 162}
The 6-hydroxytrypargine (6-HT) is an alkaloidal toxin of the group of tetrahydro-β-carbolines (THβC) isolated from the venom of the colonial spider Parawixia bistriata. These alkaloids are reversible inhibitors of the monoamine-oxidase enzyme (MAO), with hallucinogenic, tremorigenic and anxiolytic properties. The toxin 6-HT was the first THβC chemically reported in the venom of spiders; however, it was not functionally well characterized up to now. The action of 6-HT was investigated by… 
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