Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of breast cancer cell membranes.

@article{Hanikolu2019EffectsOS,
  title={Effects of Somatostatin, Curcumin and Quercetin on the fatty acid profile of breast cancer cell membranes.},
  author={Aysegul Hanikoğlu and Ertan Kucuksayan and Ferhat Hanikoglu and Tomris Ozben and Georgia Menounou and Anna Sansone and Chryssostomos Chatgilialoglu and Giuseppe Alberto Di Bella and Carla Ferreri},
  journal={Canadian journal of physiology and pharmacology},
  year={2019}
}
We used MCF-7 and MDA-MB231 breast cancer cells incubated with Curcumin and Quercetin for 24h, in the absence and presence of Somatostatin, at their EC50 concentrations, to evaluate membrane fatty acid-based functional lipidomics together with the follow-up of EGFR and MAPK signaling pathways. The two cell lines gave different membrane free fatty acid reorganization: in MCF-7 cells, the following changes observed: increase of omega-6 linoleic acid in the cells incubated with Somatostatin… 

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