Effects of Smilaxchinoside A and Smilaxchinoside C, Two Steroidal Glycosides from Smilax riparia, on Hyperuricemia in a Mouse Model

@article{Wu2014EffectsOS,
  title={Effects of Smilaxchinoside A and Smilaxchinoside C, Two Steroidal Glycosides from Smilax riparia, on Hyperuricemia in a Mouse Model},
  author={Xiao-hui Wu and Chong-Zhi Wang and Jun Zhang and Shu-Qing Wang and Lide Han and Yan-Wen Zhang and Chun-Su Yuan},
  journal={Phytotherapy Research},
  year={2014},
  volume={28},
  pages={1822 - 1828}
}
The roots and rhizomes of Smilax riparia, called ‘Niu‐Wei‐Cai’ in traditional Chinese medicine, are believed to be effective in treating the symptoms of gout. However, the active constituents and their uricosuric mechanisms are unknown. In this study, we isolated two steroidal glycosides, named smilaxchinoside A and smilaxchinoside C, from the total saponins obtained from the ethanol extract of the roots of S. riparia. We then examined if these two compounds were effective in reducing serum… 
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References

SHOWING 1-10 OF 53 REFERENCES
Smilax riparia reduces hyperuricemia in mice as a potential treatment of gout.
TLDR
It is observed that the total saponins of S. riparia could down-regulate renal mURAT1, resulting in the enhancement of urate excretion in the kidney of hyperuricemic mice, which suggests that S. Riparia could be an active anti-gout herbal medicine, which would contribute to the enhance of uric acid excretionIn the kidney.
Reparatory and preventive effects of oriental herb extract mixture (OHEM) on hyperuricemia and gout
TLDR
The positive effect of OHEM pretreatment on the prevention and treatment of hyperuricemia and gout was demonstrated and the size of gouty edema was significantly reduced following oral OHEM Pretreatment.
Effect and mechanism of total saponin of Dioscorea on animal experimental hyperuricemia.
TLDR
Investigation of the effects and mechanisms of Total Saponin of Dioscorea on animal experimental hyperuricemia showed that TSD possesses a potent anti-hyperuricemic effect on hyperURicemic animals, and the mechanism may be relevant in accelerating the excretion and decreasing the production of uric acid.
Anti-hyperuricemic and nephroprotective effects of Modified Simiao Decoction in hyperuricemic mice.
Antioxidant activities of saponins extracted from Radix Trichosanthis: an in vivo and in vitro evaluation
TLDR
RT saponins in n-butanol fraction might be a potential antioxidant candidate, as CCl4-induced oxidative stress has been found to be alleviated, which may be associated with the time dependent manner of n- butanol sapon ins in a low dose.
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