Effects of Silymarin on Lipid Metabolism in Rats


The efficacy of silymarin on lipid metabolism as evaluate by the changes of total lipids, cholesterol, lipoproteins and triglycerides in rats was studied. Fifty rats were divided into five groups. The group1 was fed on standard diet during all the period of experiment; group 2, 3, 4 and 5 were fed on egg yolk for 20days to induce hypercholesterolemia. Group2 received egg yolk and injected with saline solution (0.9% NaCl) during the experimental time (7 days). Groups 3, 4 and 5 received egg yolk and injected with silymarin (25, 50 and 100 mg/kg during the 7days, respectively). Animals were sacrificed after the end of treatments and blood samples were collected. The results showed significantly increase in serum total lipids, triglycerides, cholesterol, LDL (low density lipoproteins), HDL (high density lipoproteins), VLDL (very low density lipoproteins) in non treated animals compared to control, but these parameters showed highly significant decrease in animal treated with silymarin. In conclusion, silymarin reduced blood total lipids, triglycerides, total cholesterol and Lipoprotein.

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@inproceedings{Metwally2013EffectsOS, title={Effects of Silymarin on Lipid Metabolism in Rats}, author={M Metwally}, year={2013} }