Effects of Sesamin on Streptozotocin (STZ)-Induced NIT-1 Pancreatic β-Cell Damage


The protective effect of sesamin (SES) from sesame meal on NIT-1 pancreatic β-cells damaged by streptozotocin (STZ) in vitro was investigated. The cell viability, insulin secretion, the activity of superoxide dismutase(SOD), glutathione peroxidase (GSHpx) and the content of reduced glutathione (GSH) increased significantly when incubated with SES (400, 200 µg mL-1). The content of malondialdehyde (MDA), nitric oxide (NO) production, and the activity of NO synthase (NOS), inducible NOS (iNOS), decreased significantly when incubated with SES. The destructive changes of NIT-1 cells were ameliorated when treated with SES under microscopic observation. These data suggested that SES had obvious protective effect on NIT-1 pancreatic β-cells damaged by STZ, which might be related to its effects of decreasing levels of β-cell-destroying factors such as oxidative stress and NO synthesis.

DOI: 10.3390/ijms131216961

Extracted Key Phrases

7 Figures and Tables

Showing 1-10 of 23 references

Extraction of sesamin from sesame oil using macro-porous resin

  • J C Zhou, D W Feng, G Zheng
  • 2010

Effect of sesamin on immune function and proliferating cell nuclear antigen in S180 sarcoma-bearing mice

  • H L Bian
  • 2008

Inhibitory effect of sesamin on tumor growth and mechanism in H22 hepatoma-bearing mice

  • Y J Wei, H L Bian, C Zhao
  • 2008

Anti-inflammatory effect of Ulmus davidiana Planch (Ulmaceae) on collagen-induced inflammation in rats

  • I K Song, S K Kap, +4 authors H Cheorl
  • 2007

Biologically active components and nutraceuticals in sesame and related products: A review and prospect

  • P J Kanu, Z Kerui, B K Jestina, H M Zhou, H F Qian, K Zhu
  • 2007

Extraction of antioxidant from sesame cake and its activity study. Food Sci

  • Y Dong, Y Gao, B Xu
  • 2007

Association of the endothelial nitric oxide synthase(ecNOS) gene polymorphism with carotidatherosclerosis in type 2 diabetes

  • H P Ji, H K Ji, H Won
  • 2006

The protective effects of sesamin against liver damage in rodents

  • W S Wang, J Song
  • 2006

Sesamin as a natural antioxidant

  • Q Z Jin, Y F Liu, X G Wang, H P Dai
  • 2005