Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression.

@article{Cha2018EffectsOS,
  title={Effects of Serotonin Transporter Gene Variation on Impulsivity Mediated by Default Mode Network: A Family Study of Depression.},
  author={Jiook Cha and Guia Guffanti and Jay A Gingrich and Ardesheer Talati and P. A. J. N. Wickramaratne and Myrna M. Weissman and Jonathan E Posner},
  journal={Cerebral cortex},
  year={2018},
  volume={28 6},
  pages={
          1911-1921
        }
}
Serotonergic neurotransmission, potentially through effects on the brain's default mode network (DMN), may regulate aspects of attention including impulse control. Indeed, genetic variants of the serotonin transporter (5-HTT) have been implicated in impulsivity and related psychopathology. Yet it remains unclear the mechanism by which the 5-HTT genetic variants contribute to individual variability in impulse control. Here, we tested whether DMN connectivity mediates an association between the 5… CONTINUE READING
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