Effects of Selenium-Containing Compounds and Their Metabolism in Intact Rats and in Animals with Bone Fractures

@article{Petrovich2004EffectsOS,
  title={Effects of Selenium-Containing Compounds and Their Metabolism in Intact Rats and in Animals with Bone Fractures},
  author={Yu. A. Petrovich and R. P. Podorozhnaya and S. M. Kichenko and M. V. Kozlova},
  journal={Bulletin of Experimental Biology and Medicine},
  year={2004},
  volume={137},
  pages={74-77}
}
Blood content of MDA in rats increased 1 and 2 weeks after mandibular bone fracture at stages of cellular fibrous and chondroid callus and decreased 4 weeks after fracture at the stage of primary bone callus. Treatment with Se (intragastrically and electrophoretically) reduced this increase by activating selenium-containing glutathione peroxidase. In order to clear out the relationship between Se and carbohydrate metabolism in different ages, the distribution of Se between the blood and… 
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References

SHOWING 1-8 OF 8 REFERENCES
Low-selenium diet, bone, and articular cartilage in rats.
The pathophysiology of secondary osteoarthritis remains largely obscure. Our attention has been drawn to Kashin-Beck disease (KBD), which has been attributed to Se deficiency. To obtain information
A biomechanical and spectroscopic study of bone from rats with selenium deficiency and toxicity
TLDR
In FTIR spectroscopy, the disappearance and/or reduction of the intensities of some carbonate bands in the two experimental groups indicate that there is a decrease in crystallinity and mineral contents which, together with X-ray diffraction analysis, correlate very well with the biomechanical data.
Effects of selenium on the structure of the mandible in experimental diabetics.
TLDR
The results of this study suggest the positive effects of selenium on diabetes-induced structural alterations in the mandible, however, the unexpected results in the Selenium given control group necessitate further studies on the mechanism of seenium effects in organisms.
Selenium Deficiency‐Induced Growth Retardation Is Associated with an Impaired Bone Metabolism and Osteopenia
TLDR
It is shown that growth retardation induced by selenium deficiency is associated with impaired bone metabolism and osteopenia in second‐generation selenia‐deficient rats.
Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats.
TLDR
Evidence is provided that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietarySelenium.
Deposition of copper, manganese, zinc, and selenium in bovine fetal tissue at different stages of gestation.
TLDR
Results indicate the normal changes that occur in tissue concentrations of minerals in the developing bovine fetus and reflect fetal demands for growth and the ability of the dam to transfer minerals.
Free-Radical Oxidation and Antioxidant Systems (Theory, Clinical Application, Methods) [in Russian
  • 1992
Selenium in Human Body. Metabolism, Antioxidant Characteristics, and Role in Carcinogenesis
  • [in Russian],
  • 2002