Effects of Selenium-Containing Compounds and Their Metabolism in Intact Rats and in Animals with Bone Fractures

  title={Effects of Selenium-Containing Compounds and Their Metabolism in Intact Rats and in Animals with Bone Fractures},
  author={Yu. A. Petrovich and R. P. Podorozhnaya and S. M. Kichenko and M. V. Kozlova},
  journal={Bulletin of Experimental Biology and Medicine},
Blood content of MDA in rats increased 1 and 2 weeks after mandibular bone fracture at stages of cellular fibrous and chondroid callus and decreased 4 weeks after fracture at the stage of primary bone callus. Treatment with Se (intragastrically and electrophoretically) reduced this increase by activating selenium-containing glutathione peroxidase. In order to clear out the relationship between Se and carbohydrate metabolism in different ages, the distribution of Se between the blood and… 
The effect of zymosan and the protective effect of various antioxidants on fracture healing in rats
Free oxygen radicals demonstrate a negative effect on fractures healing and vitamin C (an antioxidant) partially prevents the negative effect of zymosan on fracture healing.
Relationship between blood malondialdehyde and catalase concentrations and the time of occurrence of non-fixed long bone fractures in dogs.
It is affirmed that all methods and treatment options that would reduce blood MDA concentrations in the early post fracture period and at the same time maintain an adequate level of the antioxidant defense, would be beneficial for the timely and proper bone healing.
Time course of serum malondialdehyde concentrations as a marker of oxidative stress in experimental canine osteotomies fixed by two different techniques
It was concluded that serum МDA concentrations in dogs with experimental tibial osteotomy depended on the used method of osteosynthesis and that a therapy with antioxidants would be probably beneficial during the first month of fracture operative treatment.
Does long-term ischemia affect the oxidant status during fracture healing?
It is concluded that complete acute transient ischemia affects the oxidant status during fracture healing, especially during the ischemic period, inflammation, and callus formation of fracture healing.
Acute and subchronic co-administrations to cadmium, diazinon and selenium induce apparent osteoporotic symptoms in adult male rats
This study demonstrates for the first time that acute and subchronic co-administrations to Cd, DZN and Se induce evident manifestation characteristics of osteoporosis in male rats.
The effects of grapeseed extract and low level laser therapy administration on the liver in experimentally fractured mandible
It was determined that the oxidative damage caused by mandibular defects could be eliminated substantially in the rat liver especially with the administration of grapeseed that has antioxidant capacity.
Effect of alpha-tocopherol on bone formation during distraction osteogenesis: a rabbit model
The results of this study show that alpha-tocopherol has beneficial effects on new bone formation during distraction osteogenesis.
Alteration of osteocalcin mRNA expression in ovine osteoblasts in dependence of sodium fluoride and sodium selenite medium supplementation.
expression of OCN mRNA in all groups except control could be promoted by F and/or Se showing a general upregulation, and the toxicity from excessive exposure of osteoblast with F could be circumvented by usage of moderate concentration of Se.
Reduction of Total Antioxidant Capacity after Femoral Fracture.
It is suggested that TAC may be decreased in considerable amounts during the first 2 weeks of fracture healing in patients with isolated closed femoral fracture.
Time-dependent changes in serum nitric oxide levels after long bone fracture.
The present study suggests that NO production may be increased in considerable amounts during the first 2 weeks of fracture healing, particularly in the first 6 hours, with a significant difference observed at the 6 hrs and on the 7th day.


Low-selenium diet, bone, and articular cartilage in rats.
The pathophysiology of secondary osteoarthritis remains largely obscure. Our attention has been drawn to Kashin-Beck disease (KBD), which has been attributed to Se deficiency. To obtain information
A biomechanical and spectroscopic study of bone from rats with selenium deficiency and toxicity
In FTIR spectroscopy, the disappearance and/or reduction of the intensities of some carbonate bands in the two experimental groups indicate that there is a decrease in crystallinity and mineral contents which, together with X-ray diffraction analysis, correlate very well with the biomechanical data.
Effects of selenium on the structure of the mandible in experimental diabetics.
The results of this study suggest the positive effects of selenium on diabetes-induced structural alterations in the mandible, however, the unexpected results in the Selenium given control group necessitate further studies on the mechanism of seenium effects in organisms.
Selenium Deficiency‐Induced Growth Retardation Is Associated with an Impaired Bone Metabolism and Osteopenia
It is shown that growth retardation induced by selenium deficiency is associated with impaired bone metabolism and osteopenia in second‐generation selenia‐deficient rats.
Developmental and postdevelopmental uptake of dietary organic and inorganic selenium into the molar teeth of rats.
Evidence is provided that selenium incorporated into developing proteins as selenotrisulfides or selenoamino acids may be responsible for the increases in dental caries reported in man and experimental animals ingesting somewhat increased amounts of dietarySelenium.
Deposition of copper, manganese, zinc, and selenium in bovine fetal tissue at different stages of gestation.
Results indicate the normal changes that occur in tissue concentrations of minerals in the developing bovine fetus and reflect fetal demands for growth and the ability of the dam to transfer minerals.
Free-Radical Oxidation and Antioxidant Systems (Theory, Clinical Application, Methods) [in Russian
  • 1992
Selenium in Human Body. Metabolism, Antioxidant Characteristics, and Role in Carcinogenesis
  • [in Russian],
  • 2002