Effects of Selective Neonatal Amygdala Damage on Concurrent Discrimination Learning and Reinforcer Devaluation in Monkeys

@article{Kazama2013EffectsOS,
  title={Effects of Selective Neonatal Amygdala Damage on Concurrent Discrimination Learning and Reinforcer Devaluation in Monkeys},
  author={AM Kazama and Jocelyne Bachevalier},
  journal={Journal of psychology \& psychotherapy},
  year={2013},
  volume={Suppl 7}
}
Objectives The amygdala is known to be a key neural structure in many neuropsychiatric disorders. Primarily known for its involvement in fear regulation, the amygdala also plays a critical role in appetitive flexible decision-making. Yet, its contribution to the development of flexible goal-directed behavior has not been thoroughly examined. Design The current study examined flexible decision-making abilities after neonatal amygdala lesions in nonhuman primates using a behavioral paradigm known… 

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References

SHOWING 1-10 OF 72 REFERENCES
Selective Bilateral Amygdala Lesions in Rhesus Monkeys Fail to Disrupt Object Reversal Learning
TLDR
The results demonstrate that the amygdala makes a selective contribution to stimulus–reward association and implicate a critical contribution to object reversal learning of structures nearby the amygdala, perhaps the subjacent rhinal cortex.
Preserved stimulus-reward and reversal learning after selective neonatal orbital frontal areas 11/13 or amygdala lesions in monkeys
Amygdala and Orbitofrontal Cortex Lesions Differentially Influence Choices during Object Reversal Learning
TLDR
It is demonstrated that the OFC and AMG make different contributions to object reversal learning not highlighted previously, based on trial-by-trial analyses of rewarded and unrewarded choices.
Control of Response Selection by Reinforcer Value Requires Interaction of Amygdala and Orbital Prefrontal Cortex
TLDR
Rhesus monkeys with surgical disconnection of these two structures, achieved by crossed unilateral lesions of the amygdala in one hemisphere and orbital prefrontal cortex in the other, combined with forebrain commissurotomy were unable to adjust their choice behavior after a change in the outcome.
Bilateral Orbital Prefrontal Cortex Lesions in Rhesus Monkeys Disrupt Choices Guided by Both Reward Value and Reward Contingency
TLDR
The pattern of results suggests that the orbital prefrontal cortex is critical for response selection based on predicted reward outcomes, regardless of whether the value of the outcome is predicted by affective signals (reinforcer devaluation) or by visual signals conveying reward contingency (object reversal learning).
Excitotoxic Lesions of the Amygdala Fail to Produce Impairment in Visual Learning for Auditory Secondary Reinforcement But Interfere with Reinforcer Devaluation Effects in Rhesus Monkeys
TLDR
The results are consistent with the idea that the amygdala is necessary for learning the association between stimuli and the value of particular food rewards; however, it is not necessary for maintaining thevalue of secondary reinforcers, once they have been learned.
GABAA-Mediated Inhibition of Basolateral Amygdala Blocks Reward Devaluation in Macaques
TLDR
It is shown that basolateral amygdala (BLA) is necessary for the appropriate registration of the change in the reinforcer value but not for the subsequent expression of the devaluation involving its transfer to secondary reinforcers.
Combined unilateral lesions of the amygdala and orbital prefrontal cortex impair affective processing in rhesus monkeys.
TLDR
Although the results provide no support for a hemispheric specialization of function, they yield the novel finding that unilateral lesions of the amygdala-orbitofrontal cortical circuit in monkeys are sufficient to significantly disrupt affective processing.
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