Effects of SR48968, a selective non-peptide NK2 receptor antagonist on emotional processes in rodents

@article{Griebel2001EffectsOS,
  title={Effects of SR48968, a selective non-peptide NK2 receptor antagonist on emotional processes in rodents},
  author={Guy Griebel and Ghislaine Perrault and Philippe Soubri{\'e}},
  journal={Psychopharmacology},
  year={2001},
  volume={158},
  pages={241-251}
}
Rationale: It has been suggested that tachykinin NK2 receptor antagonists may have therapeutic utility in anxiety and/or depressive disorders. Objective: The present study investigated the modulatory action of the NK2 receptor antagonist SR48968 on emotional processes in rodents. Methods: The tests used include classical models of anxiety (punished lever pressing and punished drinking conflict tests, elevated plus-maze in rats), a model based on defensive behaviors of mice confronted with a… CONTINUE READING
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Antidepressant - like profile of the selective NK 2 receptor antagonist , SR 48968

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Effects of the NK 2 receptor antagonist , SR 48968 on the CRFinduced activation of the NE locus coeruleusprefrontal cortex system of the rat

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