Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.

@article{Michaud1998EffectsOS,
  title={Effects of SR140333, a selective non-peptide NK1 receptor antagonist, on trigemino-thalamic nociceptive pathways in the rat.},
  author={J C Michaud and Richard Alonso and Christiane Gueudet and Mario Fournier and Roselyne Calassi and J. C. Breli{\`e}re and G{\'e}rard Le Fur and Philippe Soubri{\'e}},
  journal={Fundamental & clinical pharmacology},
  year={1998},
  volume={12 1},
  pages={88-94}
}
Trigeminal stimulation of C-fibers increased c-fos expression within the trigeminal nucleus caudalis (NtV) and thalamic neuronal activity which both reflect the transmission of a nociceptive message. We examined the effects on both these phenomena of the selective NK1 and NK2 receptor antagonists, SR140333 and SR48968. SR140333 (0.3, 1 and 3 micrograms/kg intravenously [i.v.]) dose-dependently, reversibly and stereoselectively antagonized the increase of contralateral thalamic activity. This… CONTINUE READING