Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction

  title={Effects of S1P on skeletal muscle repair/regeneration during eccentric contraction},
  author={Chiara Sassoli and Lucia Formigli and Francesca Bini and A. Meziane Tani and Roberta Squecco and Chiara Battistini and Sandra Zecchi-Orlandini and Fabio Francini and Elisabetta Meacci},
  booktitle={Journal of cellular and molecular medicine},
Skeletal muscle regeneration is severely compromised in the case of extended damage. The current challenge is to find factors capable of limiting muscle degeneration and/or potentiating the inherent regenerative program mediated by a specific type of myoblastic cells, the satellite cells. Recent studies from our groups and others have shown that the bioactive lipid, sphingosine 1-phosphate (S1P), promotes myoblast differentiation and exerts a trophic action on denervated skeletal muscle fibres… CONTINUE READING
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