Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2

@inproceedings{Gordon2009EffectsOS,
  title={Effects of S1 Cleavage on the Structure, Surface Export, and Signaling Activity of Human Notch1 and Notch2},
  author={Wendy Ryan Gordon and Didem Vardar-Ulu and Sarah L'heureux and Todd D Ashworth and Michael J. Malecki and Cheryll Sanchez-Irizarry and Debbie G. McArthur and Gavin Histen and Jennifer L. Mitchell and Jon C Aster and Stephen C Blacklow},
  booktitle={PloS one},
  year={2009}
}
BACKGROUND Notch receptors are normally cleaved during maturation by a furin-like protease at an extracellular site termed S1, creating a heterodimer of non-covalently associated subunits. The S1 site lies within a key negative regulatory region (NRR) of the receptor, which contains three highly conserved Lin12/Notch repeats and a heterodimerization domain (HD) that interact to prevent premature signaling in the absence of ligands. Because the role of S1 cleavage in Notch signaling remains… CONTINUE READING

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