Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy.

  title={Effects of S-ethyl hexahydro-1H-azepine-1-carbothioate (molinate) on di-n-butyl dichlorovinyl phosphate (DBDCVP) neuropathy.},
  author={Angelo Moretto and Giulio Gardiman and Susi Panfilo and Marie-Anne Colle and Edward A. Lock and Marcello Lotti},
  journal={Toxicological sciences : an official journal of the Society of Toxicology},
  volume={62 2},
  • A. Moretto, G. Gardiman, M. Lotti
  • Published 1 August 2001
  • Biology, Chemistry, Medicine
  • Toxicological sciences : an official journal of the Society of Toxicology
Certain esterase inhibitors protect from organophosphate-induced delayed polyneuropathy (OPIDP) when given before a neuropathic organophosphate by inhibiting neuropathy target esterase (NTE). In contrast, they can exaggerate OPIDP when given afterwards and this effect (promotion) is associated with inhibition of another esterase (M200). In vitro sensitivities of hen, rat, and human NTE and M200 to the active metabolites of molinate, sulfone, and sulfoxide, were similar. NTE and M200 were… 

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