Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder.

@article{Levkovitz2012EffectsOS,
  title={Effects of S-adenosylmethionine augmentation of serotonin-reuptake inhibitor antidepressants on cognitive symptoms of major depressive disorder.},
  author={Yechiel Levkovitz and Jonathan E. Alpert and Carrie E. Brintz and David Mischoulon and George I. Papakostas},
  journal={Journal of affective disorders},
  year={2012},
  volume={136 3},
  pages={1174-8}
}
BACKGROUND Major depressive disorder (MDD) is often accompanied by significant cognitive impairment, and there are limited interventions specific to this particular symptom. S-adenosyl methionine (SAMe), a naturally occurring molecule which serves as a major methyl-donor in human cellular metabolism, is required for the synthesis and maintenance of several neurotransmitters that have been implicated in the pathophysiology and treatment of cognitive dysfunction in MDD. METHODS This study is a… CONTINUE READING

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