Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart

  title={Effects of Rotigaptide and RIC on Ischemia Reperfusion Injury in the In Vitro Rabbit Heart},
  author={R. Salman and J. Johnsen and Thomas Ravn Lassen and Rie Schultz Hansen and H. B{\o}tker and M. Schmidt},
  • R. Salman, J. Johnsen, +3 authors M. Schmidt
  • Published 2017
  • Medicine
  • Background: Remote Ischemic Preconditioning (rIPC) and the antiarrhythmic peptide analogue, Rotigaptide (ZP123), protects against myocardial ischemia-reperfusion injury through potentially similar mechanisms. We aimed to study whether the cardioprotective effects of Rotigaptide and rIPC interacts. Methods: We used male New Zealand White rabbit hearts mounted in a Langendorff system and exposed to 30 min of global no-flow ischemia and 120 min of reperfusion. A total of 48 rabbits were randomized… CONTINUE READING
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