Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging

@article{Sarubbo2018EffectsOR,
  title={Effects of Resveratrol and other Polyphenols on Sirt1: Relevance to Brain Function During Aging},
  author={Fiorella Sarubbo and Susana Esteban and Antonio Miralles and David Moranta},
  journal={Current Neuropharmacology},
  year={2018},
  volume={16},
  pages={126 - 136}
}
Background Classically the oxidative stress and more recently inflammatory processes have been identified as the major causes of brain aging. Oxidative stress and inflammation affect each other, but there is more information about the effects of oxidative stress on aging than regarding the contribution of inflammation on it. Methods In the intense research for methods to delay or mitigate the effects of aging, are interesting polyphenols, natural molecules synthesized by plants (e.g… Expand
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References

SHOWING 1-10 OF 183 REFERENCES
Flavonoids and the aging brain.
TLDR
Several reports support the concept that flavonoid intake inhibits certain biochemical processes of brain aging, and might thus prevent to some extent the decline of cognitive functions with aging as well as the development or the course of neurodegenerative diseases. Expand
Vascular dysfunction in aging: potential effects of resveratrol, an anti-inflammatory phytoestrogen.
TLDR
This review focuses on the role of oxidative stress and inflammation in cardiovascular dysfunction in aging, and on emerging anti-aging therapeutic strategies offered by resveratrol and other polyphenol compounds. Expand
Regulation of inflammation and redox signaling by dietary polyphenols.
TLDR
The recent data suggest that dietary polyphenols can work as modifiers of signal transduction pathways to elicit their beneficial effects during oxidative stress, their metabolism and bioavailability. Expand
Regulation of SIRT1 in cellular functions: role of polyphenols.
TLDR
Activation of SIRT1 by polyphenols is beneficial for regulation of calorie restriction, oxidative stress, inflammation, cellular senescence, autophagy/apoptosis, autoimmunity, metabolism, adipogenesis, circadian rhythm, skeletal muscle function, mitochondria biogenesis and endothelial dysfunction. Expand
The beneficial effects of fruit polyphenols on brain aging
TLDR
Research from the laboratory has shown that nutritional antioxidants, such as the polyphenols found in blueberries, can reverse age-related declines in neuronal signal transduction as well as cognitive and motor deficits and that short-term blueberry supplementation increases hippocampal plasticity. Expand
Bioactive effects of quercetin in the central nervous system: Focusing on the mechanisms of actions.
TLDR
The current review focuses on summarizing the recent findings on the neuroprotective effect of quercetin, its mechanism of action and its possible roles in the prevention of neurological disorders. Expand
Polyphenols and aging.
TLDR
While the mechanisms by which these effects occur are yet to be fully understood, it is evident that further investigation may yield a potential use for polyphenols as pharmacological interventions against specific age-associated diseases. Expand
Protective effects and mechanisms of sirtuins in the nervous system
TLDR
The distribution of sirtuins in the brain and how their expression and activity are regulated are introduced, and the mechanisms underlying sirtuin-mediated neuroprotection are analyzed, centering on their non-histone substrates such as DNA repair enzymes, protein kinases, transcription factors, and coactivators. Expand
Sirtuins: from metabolic regulation to brain aging
  • W. Duan
  • Biology, Medicine
  • Front. Aging Neurosci.
  • 2013
Brain aging is characterized by progressive loss of neurophysiological functions that is often accompanied by age-associated neurodegeneration. Calorie restriction has been linked to extension ofExpand
Polyphenols, intracellular signalling and inflammation.
TLDR
This review will discuss recent data on the control of inflammatory signalling exerted by some dietary polyphenols contained in Mediterranean diet. Expand
...
1
2
3
4
5
...