Effects of Reserpine Pre-treatment on the Protective Action of Amphetamine and Phenoxypropazine in the Phenylbenzoquinone-induced Writhing Syndrome in Mice

@article{Davis1964EffectsOR,
  title={Effects of Reserpine Pre-treatment on the Protective Action of Amphetamine and Phenoxypropazine in the Phenylbenzoquinone-induced Writhing Syndrome in Mice},
  author={RUTH A. Davis and M. Horlington},
  journal={Nature},
  year={1964},
  volume={201},
  pages={306-307}
}
A RECENT publication by Okun et al.1 described the protective action of amphetamine on the ‘writhing syndrome’. In independent experiments we also found amphetamine to be active and some results extending these observations are described in this communication. 
Synthesis, anti-inflammatory, analgesic and anticonvulsant activities of 1,8-dihydro-1-ary1-8-alkyl pyrazolo(3,4-b)indoles
TLDR
The newly synthesized compounds were evaluated for their anti-inflammatory, analgesic and anticonvulsant activities compared to indomethacin, flufenamic acid and diazepam as positive controls.
Synthesis and potential biological activity of some novel 3-[(N-substituted indol-3-yl)methyleneamino]-6-amino-4-aryl-pyrano(2,3-c)pyrazole-5-carbonitriles and 3,6-diamino-4-(N-substituted indol-3-yl)pyrano(2,3-c)pyrazole-5-carbonitriles
TLDR
Most of the newly synthesized compounds possess potential antimicrobial activity against Escherichia coli and Pseudomonas aeruginosa and the anticonvulsant potency of certain tested compounds was more pronounced than both anti-inflammatory and analgesic activities.

References

SHOWING 1-4 OF 4 REFERENCES
Effect of D-Amphetamine on Rat Brain Noradrenaline and Serotonin
  • J. McLean, M. McCartney
  • Biology, Psychology
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine
  • 1961
Summary The treatment of rats with D-amphetamine sulfate lowered brain noradrenaline and slightly elevated brain serotonin. These effects lasted for several days after discontinuing treatment.