Effects of Rapid Tryptophan Depletion on Sleep Electroencephalogram and Mood in Subjects with Partially Remitted Depression on Bupropion

@article{Evans2002EffectsOR,
  title={Effects of Rapid Tryptophan Depletion on Sleep Electroencephalogram and Mood in Subjects with Partially Remitted Depression on Bupropion},
  author={Lynn Evans and Shahrokh Golshan and John Kelsoe and Mark Rapaport and Kathryn Resovsky and Laura D. Sutton and J. Christian Gillin},
  journal={Neuropsychopharmacology},
  year={2002},
  volume={27},
  pages={1016-1026}
}
Serotonin has been implicated in both sleep and mood regulation. When central serotonin was depleted with a tryptophan-free amino acid drink (TFD), some studies have reported that the antidepressant benefits were reversed in partially remitted patients treated with SSRIs. Other studies showed that the TFD increased rapid eye movement (REM) sleep in both normal males and in remitted depression patients on selective serotonin reuptake inhibitors (SSRIs) without affecting mood. In this study, we… CONTINUE READING
10 Citations
59 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 10 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 59 references

Development of a rating scale for primary depressive illness

  • M Hamilton
  • Br J Soc Clin Psychol
  • 1967
Highly Influential
4 Excerpts

Similar Papers

Loading similar papers…