Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.

@article{Xiang2003EffectsOR,
  title={Effects of RNase L mutations associated with prostate cancer on apoptosis induced by 2',5'-oligoadenylates.},
  author={Ying Xiang and Zhengfu Wang and Junko Murakami and Sarah J. Plummer and Eric A Klein and John D. Carpten and Jeffrey M. Trent and William B Isaacs and Graham R Casey and Robert H. Silverman},
  journal={Cancer research},
  year={2003},
  volume={63 20},
  pages={6795-801}
}
The RNASEL gene, a strong candidate for the hereditary prostate cancer 1 allele (HPC1), encodes a single-stranded specific endoribonuclease involved in the antiviral actions of IFNs. RNase L is activated enzymatically after binding to unusual 5'-phosphorylated, 2',5'-linked oligoadenylates (2-5A). Biostable phosphorothioate analogues of 2-5A were synthesized chemically and used to study the effects of naturally occurring mutations and polymorphisms in RNASEL. The 2-5A analogues induced RNase L… CONTINUE READING

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RNASEL Arg 462 Gln variant is implicated in up to 13 % of prostate cancer cases

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