Effects of RNA branching on the electrostatic stabilization of viruses.
@article{ErdemciTandogan2016EffectsOR, title={Effects of RNA branching on the electrostatic stabilization of viruses.}, author={Gonca Erdemci-Tandogan and Jef Wagner and Paul van der Schoot and R. Podgornik and Roya Zandi}, journal={Physical review. E}, year={2016}, volume={94 2-1}, pages={ 022408 } }
Many single-stranded (ss) ribonucleic acid (RNA) viruses self-assemble from capsid protein subunits and the nucleic acid to form an infectious virion. It is believed that the electrostatic interactions between the negatively charged RNA and the positively charged viral capsid proteins drive the encapsidation, although there is growing evidence that the sequence of the viral RNA also plays a role in packaging. In particular, the sequence will determine the possible secondary structures that the…
26 Citations
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It is shown that an increase in effective chain stiffness because of base-pairing could be the reason why under certain conditions linear chains have an advantage over branched chains when it comes to encapsidation efficiency.
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