Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity.

@article{Grupp1980EffectsOR,
  title={Effects of RMI 12330A, a new inhibitor of adenylate cyclase on myocardial function and subcellular activity.},
  author={G. Grupp and Ingrid L. Grupp and Carl L. Johnson and Mohammed A. Matlib and William Rouslin and A. Truman Schwartz and Earl Taylor Wallick and Tian-ming Wang and P. Lewis Wisler},
  journal={British journal of pharmacology},
  year={1980},
  volume={70 3},
  pages={
          429-42
        }
}
1 RMI 12330A, a lactam-imine, at concentrations of 10(-4) M and higher, inhibited basal as well as isoprenaline and NaF-stimulated adenylate cyclase activity of guinea-pig heart homogenates. However, RMI 12330A was a more potent inhibitor of histamine-stimulated adenylate cyclase (IC50 of 1.5 X 10(-5) M). 2 In the isolated work-performing heart of the guinea-pig, RMI 12330A (IC50 of 1.1 X 10(-6) M) depressed all cardiac functions: pressures developed, dP/dt, contractile force, dF/dt, work… CONTINUE READING
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