Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells.

@article{Cvijic1998EffectsOR,
  title={Effects of RIalpha overexpression on cisplatin sensitivity in human ovarian carcinoma cells.},
  author={Mary Ellen Cvijic and K V Chin},
  journal={Biochemical and biophysical research communications},
  year={1998},
  volume={249 3},
  pages={723-7}
}
Our laboratory has found that Chinese hamster ovary (CHO) and mouse Y1 adrenocortical carcinoma PKA mutants with a defective R subunit, but not altered C subunits, exhibit increased resistance to cisplatin as well as other DNA-damaging agents. The mechanism of resistance may be associated with increased recognition of the cisplatin-damaged DNA and protein binding to the DNA lesion, thus enhancing DNA repair in the RI alpha mutants. These data suggest that mutation of RI alpha may confer… CONTINUE READING

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