Effects of Psychotropic Drugs on Seizure Threshold

@article{Pisani2002EffectsOP,
  title={Effects of Psychotropic Drugs on Seizure Threshold},
  author={Francesco Pisani and Giancarla Oteri and Cinzia Costa and G. Di Raimondo and Raoul Di Perri},
  journal={Drug Safety},
  year={2002},
  volume={25},
  pages={91-110}
}
Psychotropic drugs, especially antidepressants and antipsychotics, may give rise to some concern in clinical practice because of their known ability to reduce seizure threshold and to provoke epileptic seizures. Although the phenomenon has been described with almost all the available compounds, neither its real magnitude nor the seizurogenic potential of individual drugs have been clearly established so far. In large investigations, seizure incidence rates have been reported to range from ∼0.1… 
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The evidence shows that the majority of psychotropic medications are not proconvulsant when used in therapeutic doses with the exception of a subset of medications, mainly bupropion IR and certain antipsychotic drugs such as clozapine.
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